Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nucleic acid aptamers specifically combined with beta-amyloid precursor protein lyase 1 and application of aptamers

A nucleic acid aptamer, precursor protein technology, applied in the field of biomedicine

Active Publication Date: 2015-01-21
SOUTHERN MEDICAL UNIVERSITY
View PDF1 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these studies are preliminary, they show the potential of aptamers in the diagnosis and treatment of CNS diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nucleic acid aptamers specifically combined with beta-amyloid precursor protein lyase 1 and application of aptamers
  • Nucleic acid aptamers specifically combined with beta-amyloid precursor protein lyase 1 and application of aptamers
  • Nucleic acid aptamers specifically combined with beta-amyloid precursor protein lyase 1 and application of aptamers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Screening of aptamers that bind to the extracellular region of BACE1 and have inhibitory activity using a microwell plate method

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses nucleic acid aptamers specifically combined with beta-amyloid precursor protein lyase 1 and an application of the nucleic acid aptamers. The nucleotide sequences of the nucleic acid aptamers are any one of SEQ ID NO: 1 and SEQ ID NO: 2. The nucleic acid aptamers or chemical modifiers of the nucleic acid aptamers serving as BACE1 inhibitors can be applied to preparing drugs for treating Alzheimer's disease. The DNA aptamers A1 and A4 which can be combined with BACE1 with high affinity are successfully screened by virtue of an SELEX technology in the research, and the aptamers have the effect of inhibiting the in vitro activity of the BACE1. The nucleic acid aptamers are used for providing a research basis on development of novel potent and specific BACE1 inhibitors and providing novel methods and concepts to treatment of AD.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and specifically relates to a nucleic acid aptamer specifically combined with β-amyloid precursor protein lyase 1 and an application thereof. Background technique: [0002] Alzheimer's disease (AD) is a progressive degenerative disease of the central nervous system, with cognitive dysfunction as the main clinical manifestation, and other symptoms including executive dysfunction and mental disorders. Advanced patients cannot take care of themselves and often die from complications such as lung infection; it brings huge economic burden to the patient's family and society [1] . It is predicted that the number of AD patients worldwide will triple from 36 million in 2010 to 2050 [2] . The cause of AD is unknown. At present, it is believed that a variety of pathogenic factors, such as amyloid precursor protein / amyloidβ (APP / Aβ) [3] , Apolipoprotein E4 (ApolipoproteinE4, apoE4) [4,5] 、tau [6,7] , α-sy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12N15/115A61K48/00A61P25/28
Inventor 石玉生张兴梅梁惠玉陈文君彭勇华
Owner SOUTHERN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com