Gradient-method vacuumizing process and device for full-pressure-plug antibiotics bottle

Abstract

The invention relates to a gradient-method vacuumizing process and device for a full-pressure-plug antibiotics bottle. The device comprises a hydraulic hoisting column, a box body, a pressing plate and a vacuum pipeline arranged on the box body, wherein the upper surface of the pressing plate is connected with the bottom of the hydraulic hoisting column and a bottle containing frame plate assembly with a buffering plate is arranged at the lower part; a front door with pneumatic hoisting is arranged on one side of the box body and a frame pushing rod is arranged on the opposite surface of the front door; an adjustable vacuum pipeline, a re-pressing pipeline and a washing and sterilizing device are arranged above the box body; the vacuum pipeline is provided with a valve piece I and a valve piece II which are parallel to each other; clean air is filtered by a filter and enters the box body from the re-pressing pipeline; powder is filled and the full-pressure-plug antibiotics bottles are sequentially arrayed and are arranged into the bottle containing frame plate assembly with the buffering plate; then the bottle containing frame plate assembly is pushed into the box body to be sealed; at the moment, the distance from the position of the pressing plate in the box body to a bottle plug is not more than 1.2 times the height of the plug. The gradient-method vacuumizing process adopts three times of vacuumizing, two times of plug pressing and two times of re-pressing so that the remaining oxygen of a powder injection type antibiotics bottled product is 3%-7%.

Description

technical field [0001] The patent of the present invention relates to a gradient method vacuum pumping process and device for fully plugging antibiotic bottles, which is suitable for cefotiam hydrochloride for injection, cefmenoxime hydrochloride powder injection antibiotic bottles for injection, etc. The stopper production process and equipment can ensure that the residual oxygen content of powder injection antibiotic bottled products is 3% to 7%. Background technique [0002] Antibiotic bottle freeze-dried powder injection and powder injection are non-terminal sterilized small-capacity injections, and there are many equipments, but there is no special equipment for vacuuming antibiotic bottles with full pressure stopper. [0003] At present, the following problems will be encountered in the production and quality control of powder injection products: (1) When the buffer agent anhydrous sodium carbonate is contained, it will be dissolved due to CO 2 , so there is a negativ...

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Problems solved by technology

[0003] At present, the following problems will be encountered in the production and quality control of powder injection products: (1) When the buffer agent anhydrous sodium carbonate is contained, it will be dissolved due to CO 2 , so there is a negative pressure requirement in the sealed bottle; (2) there are oxidizing chemicals, which have certain requirements for the residual oxygen in the sealed bottle

[0004] The existing vacuuming operation will use earthen plexiglass boxes for vacuuming, which are all completed in the B-level area, the speed is slow, the labor intensity is high, and the plexiglass boxes cannot be sterilized

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