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Preparation method of traditional Chinese medicine pellet

A technology for traditional Chinese medicine and pellets, applied in the field of pharmaceutical preparations and their preparation, can solve the problems of few traditional Chinese medicine products, low drug loading, instability and the like

Active Publication Date: 2014-12-24
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The drug loading technology on blank pellets has been used for many years, but there are very few traditional Chinese medicine products. Many traditional Chinese medicine drug loading technologies either have low drug loading, are unstable, or have poor appearance.

Method used

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  • Preparation method of traditional Chinese medicine pellet
  • Preparation method of traditional Chinese medicine pellet
  • Preparation method of traditional Chinese medicine pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0228] The preparation of salvia miltiorrhiza extract, the steps are as follows:

[0229] Cutting Salvia miltiorrhiza: check the appearance of medicinal materials, weigh them, and set aside.

[0230] Feeding requirements of medicinal materials:

[0231] Cut Danshen: different batches of cut Danshen can be used in appropriate proportions according to needs.

[0232] The order of adding materials: when feeding, first throw E-cut salvia miltiorrhiza, add 90±0.5% ethanol for the first decoction, and add first-grade RO water as the extraction solvent for the second decoction.

[0233] extract:

[0234] A batch consists of 2 cans, each can weighs 100kg of cut salvia miltiorrhiza according to the batch prescription, adds 400±12L of 90±0.5% ethanol, decocts for 90±5min, filters through 200 mesh, puts the two cans of alcohol extract together Put it in the static tank; extract the dregs for the second time, add 500±15L of water, decoct for 60±3min, filter through 200 mesh, discard th...

Embodiment 2

[0240] Salvia miltiorrhiza micropill capsules can be prepared according to the following methods:

[0241] Raw materials:

[0242] Danshen Extract 32.5kg

[0243] Starch based pellets 16.0kg

[0244] Opadry 85G66817 1.5kg

[0245] The preparation method is as follows:

[0246] Preparation of the medicinal solution of Danshen extract: Put the Danshen extract into the premix tank, add 0.7-0.9 times the amount of purified water, stir for more than 30 minutes, and obtain the traditional Chinese medicine liquid;

[0247] Starch-based pill loading: adjust the spray gun and atomization pressure, so that the liquid medicine can be uniformly atomized into fine droplets;

[0248] Feeding fluidization: suck the starch-based pellets into the fluidized drying coating machine, set the air volume at 600-1500m 3 / h, to make the base pellets completely fluidized in the bed, but not violently fluidized to cause the base pellets to wear and pulverize, as long as the base pellets can cover t...

Embodiment 3

[0254] Preparation of drug-loaded pellets

[0255] Feeding fluidization of base pellets: set air volume to 600m 3 / h, inhale the base pills into the fluidized drying coating machine, so that the base pills are completely fluidized in the bed body; but it cannot be violently fluidized to cause the base pills to wear and pulverize;

[0256] Initial drug loading stage: adjust the spray gun to ensure good atomization, transport the Chinese medicine liquid to the spray gun through the metering pump, set the upper spray and lower spray to 2.0Bar and 2.5Bar respectively, and set the material temperature to about 50°C. After the temperature rises to 45°C, start spraying, and set the spraying speed to 70g / min;

[0257] During the drug loading process: the material temperature is 50°C, and the infusion volume gradually increases with the increase of the pellet diameter, and the maximum infusion speed does not exceed 400g / min, and the air volume is adjusted according to the fluidization...

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Abstract

The invention relates to a traditional Chinese medicine pellet which is prepared from traditional Chinese medicine extractives or traditional Chinese medicine extracts and a base pellet according to the weight ratio of (1:5)-(5:1); and the traditional Chinese medicine pellet has the bulk density of 0.6-1.3g / ml, the specific surface area of 0.005-0.05m<2> / g and the particle size of 0.5-1.8mm. The invention also provides a preparation method of the pellet, so that the problems that traditional Chinese medicines or vegetable drugs easily absorb moisture and are unstable are solved; and the preparation method is simple, feasible and suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof. The pharmaceutical preparation refers to a pharmaceutical pellet, especially a traditional Chinese medicine or herbal medicine pellet and a preparation method thereof. Background technique [0002] The traditional preparation method of traditional Chinese medicine or herbal medicine granules is to make traditional Chinese medicine or herbal medicine or its extracts into granular substances with a certain particle size by dry method or wet method, and drink or swallow them with water when used by patients. Due to the high viscosity of traditional Chinese medicine or herbal medicine extracts, most traditional granule preparation methods have problems such as low drug loading, unsightly appearance, poor taste, and easy moisture absorption. [0003] Blank pellets are commonly used drug carriers in the preparation industry. Many commercially available capsule preparation...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61J3/06A61K36/537A61K31/192A61K31/343A61K31/216A61K31/58A61K31/702
Inventor 章顺楠杨建会孙艳张洪坡董海鸥邵星云董莉娜马永强姚风娟陈聪刘晓峰周立红李晨鸣闫希军叶正良郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD
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