Phenylacetylglutamine as biomarker for healthy ageing
A biomarker, glutamine technology, applied in the field of improvement, can solve the problems of lack of long-lived metabolic phenotype research, comprehensive description of molecular mechanism has not yet been reported, etc.
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[0136] Subjects and Study Groups
[0137] Each individual and their family gave informed consent for the study to be conducted. In total, 541 subjects belonging to different age groups were enrolled for this study in northern Italy (including Bologna, Florence, Parma, Milan). The centenarian group consisted of 156 individuals (125 females and 31 males), the older group consisted of 363 individuals (205 females and 158 males), and the young adult group consisted of 22 individuals (10 women and 12 men).
[0138] The study protocol was approved by the ethics committee of the Sant'Orsola-Malpighi University Faculty of Medicine (Bologna, Italy). Resulting biological samples (serum and urine) were stored at -80°C until metabolomic analysis.
[0139] clinical chemistry
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