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Titanium dioxide-based composite film with hierarchical nano-dot structure and preparation method thereof

A titanium dioxide and composite film technology, applied in the field of hierarchical nano-dot structure titanium dioxide-based composite film and its preparation, can solve problems such as unfavorable subsequent utilization of cells, and achieve the effects of excellent photo-induced hydrophilicity, easy popularization and application, and low cost.

Inactive Publication Date: 2016-08-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that cells tend to attach to slightly hydrophobic surfaces, but are not easy to attach to hydrophilic surfaces. At present, trypsin treatment is mainly used when harvesting cells in vitro cell culture, but trypsin treatment will make cells and extracellular matrix Separation is not conducive to the subsequent utilization of cells, so the preparation of materials that can change the wettability of the surface as a surface coating for vessels such as petri dishes is extremely valuable for cell harvesting

Method used

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  • Titanium dioxide-based composite film with hierarchical nano-dot structure and preparation method thereof
  • Titanium dioxide-based composite film with hierarchical nano-dot structure and preparation method thereof
  • Titanium dioxide-based composite film with hierarchical nano-dot structure and preparation method thereof

Examples

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Embodiment 1

[0020] 1) Add tetrabutyl titanate, acetylacetone and deionized water into absolute ethanol at a molar ratio of 1:0.3:1, then add polyvinylpyrrolidone and stir well at room temperature to prepare a titanium atomic concentration of 0.2 M, the titanium dioxide precursor sol with a polyvinylpyrrolidone concentration of 40mg / ml; drop the titanium dioxide precursor sol onto the cleaned silicon wafer surface until it is covered, and spin coat it at a speed of 8000rpm for 40s, and then place it at 500 ℃ for 1h, a titanium dioxide nano-dot layer was obtained on the silicon wafer (see figure 1 ). It can be seen from the figure that the titanium dioxide nano-dots have a size of 30nm-200nm and a density of 3.0×10 10 / cm 2 .

[0021] 2) Add zinc acetate and ethanolamine to absolute ethanol at a molar ratio of 1:1, stir well at room temperature, and prepare a zinc oxide precursor sol with a zinc atomic concentration of 0.14M; drop the zinc oxide precursor sol to Step 1) The prepared tit...

Embodiment 2

[0024] 1) Add titanium tetrachloride, acetylacetone, and deionized water to absolute ethanol at a molar ratio of 1:0.3:1, then add polyvinylpyrrolidone and stir well at room temperature to prepare a titanium atomic concentration of 0.1 M , a titanium dioxide precursor sol with a polyvinylpyrrolidone concentration of 10 mg / ml; drop the titanium dioxide precursor sol onto the cleaned titanium sheet surface until it is covered, and spin coat it at a speed of 8000 rpm for 60 seconds, and then place it at 600 ° C Keeping it warm for 2 hours, a titanium dioxide nano-dot layer is obtained on the titanium sheet. The titanium dioxide nano-dots have a size of 80nm-280nm and a density of 1.0×10 10 / cm 2 .

[0025] 2) Add zinc nitrate and ethanolamine to absolute ethanol at a molar ratio of 1:1, stir well at room temperature, and prepare a zinc oxide precursor sol with a zinc atomic concentration of 0.2M; drop the zinc oxide precursor sol to Step 1) The prepared titanium dioxide nano-d...

Embodiment 3

[0027] 1) Add titanium trichloride, ethanolamine, and deionized water to absolute ethanol at a molar ratio of 1:0.3:1, then add polyvinylpyrrolidone and stir well at room temperature to prepare a titanium atomic concentration of 0.5 M, Titanium dioxide precursor sol with a polyvinylpyrrolidone concentration of 60mg / ml; drop the titanium dioxide precursor sol onto the cleaned titanium-nickel alloy sheet surface until it is covered, and spin-coat at a speed of 4000rpm for 20s, and then place it at 400 The temperature is kept at ℃ for 1 h, and a titanium dioxide nano-dot layer is obtained on the titanium-nickel alloy sheet. The titanium dioxide nano-dots have a size of 100nm to 300nm and a density of 1.0×10 10 / cm 2 .

[0028] 2) Add ferric nitrate and acetylacetone to absolute ethanol at a molar ratio of 1:2, stir well at room temperature, and prepare an iron oxide precursor sol with an iron atomic concentration of 0.02M; drop the iron oxide precursor sol To the titanium diox...

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Abstract

The titania-based composite thin film with hierarchical nano-dot structure disclosed by the invention has a titanium dioxide nano-dot layer and a photosensitive semiconductor nano-dot layer in sequence from bottom to top. A titanium dioxide-based composite film with a hierarchical nano-dot structure is prepared by a sol-gel method. First, a titanium dioxide precursor sol is spin-coated on the substrate, annealed and dried, and a titanium dioxide nano-dot layer is obtained on the substrate, and then a photosensitive semiconductor is spin-coated on it. The precursor sol is annealed and dried to obtain a titanium dioxide-based composite film with a hierarchical nano-dot structure on the substrate. The composite film of the invention not only has excellent photo-induced hydrophilicity, but also has a large specific surface area, which is beneficial to the initial attachment, proliferation and differentiation of cells. The method of the invention is simple, low in cost, easy to popularize and apply, and can be widely used in biomedical engineering fields such as in vitro cell culture and tissue engineering.

Description

technical field [0001] The invention belongs to the field of biomedical thin films, and in particular relates to a graded nano-dot structure titanium dioxide-based composite thin film with adjustable surface hydrophilic properties and ion sustained release performance and a preparation method thereof. Background technique [0002] Surfaces and interfaces are the windows to realize the functionality of devices and materials, and the construction of surface micro-nanostructures is of great significance to the performance of materials. Micro-nano structured biomaterials have become a research hotspot and difficulty in the field of biomedical materials. A large number of studies have shown that biomaterials with micro-nanostructure characteristics have shown positive biological responses. Compared with other biomaterials, micro-nanostructure materials can significantly promote cell adhesion, proliferation and differentiation. [0003] The cellular microenvironment plays an impo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B32B33/00B32B15/04B32B17/06B32B9/04A61L27/40A61L27/10A61L27/02A61L27/04A61L27/06C12N5/00
Inventor 程逵孙俞翁文剑宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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