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Anti-epithelial cell adhesion molecule (EpCAM) antibodies and methods of use thereof

A technology of epithelial cells and adhesion molecules, applied in the direction of anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, antibody, antibody medical components, etc., can solve the problem of no obvious increase in long-term survival rate

Active Publication Date: 2014-11-26
ACAD SINIC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite significant improvements in diagnosis, local management, and chemotherapy for head and neck cancer, long-term survival has not improved significantly over the past 30 years

Method used

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  • Anti-epithelial cell adhesion molecule (EpCAM) antibodies and methods of use thereof
  • Anti-epithelial cell adhesion molecule (EpCAM) antibodies and methods of use thereof
  • Anti-epithelial cell adhesion molecule (EpCAM) antibodies and methods of use thereof

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Embodiment

[0071] The devices, methods and related results according to the embodiments of the present invention are as follows, but are not intended to limit the scope of the present invention. Note that headings or subheadings are used in the Examples for the convenience of the reader, but in no way limit the scope of the present invention. Furthermore, some theories are proposed and disclosed herein, but no matter whether these theories are right or wrong, they do not limit the scope of the present invention, as long as the present invention is implemented according to the present invention, regardless of any particular theory or action flow.

[0072] Materials and Methods

[0073]Cell lines and culture. The following human cell lines were used: oral cancer (FaDu and SAS), nasopharyngeal cancer (NPC039), ovarian cancer (SKOV-3), lung cancer (CL1-5, H441 and H520), pancreatic cancer (MIA PaCa-2), Colorectal cancer (COLO205, HCT116 and SW620), hepatocellular carcinoma (Hep3B and Mahla...

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Abstract

An isolated monoclonal antibody or an antigen-binding fragment thereof is disclosed. The antibody or the antigen-binding fragment is characterized by: (a) having a specific binding affinity to epithelial cell adhesion molecule (EpCAM) comprising the amino acid sequence of SEQ ID NO: 1; (b) having a specific binding affinity to cancer cells expressing EpCAM, said cancer cells being selected from the group consisting of oral cancer cells, nasopharyngeal cancer cells (NPC), colorectal cancer cells, and ovarian cancer cells; and(c) having no binding affinity to human umbilical vein endothelial cell (HUVEC) and normal nasal mucosal epithelia (NNM). Also disclosed is an isolated monoclonal antibody or an antigen-binding fragment thereof that has a specific binding affinity to an epitope within the sequence of KPEGALQNNDGLYDPDCDE (SEQ ID NO: 63) located within the EGF-like domain II of epithelial cell adhesion molecule (EpCAM). Methods of using the same are also disclosed.

Description

technical field [0001] The present invention relates generally to anticancer agents, and more particularly to antibodies for use in cancer treatment, diagnosis and imaging. Background technique [0002] Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in developed countries worldwide. Oral squamous cell carcinoma (OSCC) is the most common tumor in the head and neck. Despite significant improvements in diagnosis, local management, and chemotherapy for head and neck cancer, long-term survival has not increased significantly over the past 30 years. Even with modern medical services, the overall mortality rate for intraoral cancer remains high at around 50%. Therefore, the prevention, early diagnosis and treatment of high-risk precancerous lesions are very helpful in reducing HNSCC-related deaths. Contents of the invention [0003] In one aspect, the present invention relates to a purified or isolated monoclonal antibody or antigen-binding f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00A61K39/395
CPCC07K2317/24C07K2317/34C07K2317/565C07K16/30C07K2317/76C07K2317/73A61K2039/505C07K2317/56C07K2317/92C07K16/18G01N33/574A61P35/00A61P43/00
Inventor 吴汉忠廖美英林政纬
Owner ACAD SINIC
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