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Intraocular tension reducing compound and preparation method and use thereof

A compound, intraocular pressure technology, applied in the fields of organic chemistry, drug combination, sensory diseases, etc., can solve the problems of unsatisfactory treatment effect and so on

Inactive Publication Date: 2014-11-19
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the scientific community is still inconclusive about the cause of lowering intraocular pressure. It is recognized that it is caused by a variety of reasons. At present, the therapeutic effect of drugs for lowering intraocular pressure is not very satisfactory.

Method used

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  • Intraocular tension reducing compound and preparation method and use thereof
  • Intraocular tension reducing compound and preparation method and use thereof
  • Intraocular tension reducing compound and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0029] Preparation Example 1 (compound A is the preparation of compound A3)

[0030] Compound A1 was reacted at room temperature under the action of thionyl chloride and methanol for 24 hours to generate compound A2, and compound A2 was reacted in 10 volumes of ethanol solution at room temperature for 24 hours under the combined action of compounds a1 and a2 to generate compound A3.

preparation Embodiment 2

[0031] Preparation Example 2 (compound B is the preparation of compound B3)

[0032] Compound B1 was refluxed in thionyl chloride and ethanol solution for 3 hours to generate B2, and compound B2 was reacted in ethanol solution at room temperature for 24 hours under the joint action of equimolar amounts of compounds b1 and b2 to obtain compound B3.

[0033]

preparation Embodiment 3

[0035] Compound (C) was prepared in the same manner as in Preparation Example 2.

[0036]

[0037]

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PUM

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Abstract

The invention discloses a compound and a pharmaceutical composition and preparation method and use thereof, the use is the use of the compound in preparation of intraocular tension reducing drugs, and the compound has very obvious intraocular tension reducing effects.

Description

technical field [0001] The present invention relates to a class of compounds for reducing intraocular pressure and their preparation methods and uses, pharmaceutical compositions prepared from the above compounds and their pharmaceutically acceptable salts and analogs thereof, and the compounds or their pharmaceutically acceptable salts and their analogues Use of a substance in the preparation of a medicament for reducing intraocular pressure. [0002] Background technique [0003] The increase of intraocular pressure (IOP) due to various reasons is an eye disease that endangers human health all over the world. The main manifestation of patients is short-term or long-term increase of intraocular pressure. This is a very serious blinding eye disease due to the irreversible loss of vision caused by elevated intraocular pressure. [0004] At present, the scientific community is still inconclusive about the cause of lowering intraocular pressure. It is generally believed that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D405/06C07D309/40A61K31/4433A61K31/351A61P27/02
CPCC07D309/40C07D405/06
Inventor 韩冰王斓
Owner 韩冰
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