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Application of arctiin to medicines for treating gout

A technology of arctiin and burdock fruit, which is applied in the field of medicine, can solve problems such as the application of arctiin that has not been seen, and achieve the effects of developing medicinal value, simple preparation method, and developing new uses

Inactive Publication Date: 2014-11-12
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Along with the raising of the medicinal value of Arctium Fructus, more and more people of insight have carried out multifaceted research on Arctium Fructus, but so far there is no use of arctiin extracted from Arctium Fructus in preparing medicine for treating gout. application

Method used

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  • Application of arctiin to medicines for treating gout
  • Application of arctiin to medicines for treating gout
  • Application of arctiin to medicines for treating gout

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Embodiment Construction

[0008] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0009] In the specific implementation of the present invention, the application of arctiin in the preparation of medicine for the treatment of gout, the arctiin is that the arctiin is crushed into a coarse powder of 20-30 mesh sieve, and the volume concentration is 10 times of the weight of the arctiin Soak in 80% ethanol for 2 hours, reflux extraction twice, 1.5 hours each time, filter, combine the filtrates, recover the ethanol under reduced pressure until there is no alcohol smell, and concentrate to a concentrated solution with a relative density of 1.20 to 1.30 at 60°C. Disperse with distilled water so that the crude drug content is 0.5g / ml to obtain a dispersion; on the dispersion, AB-8 macroporous adsorption resin, the ratio of sample volume to resin volume is 1:10, and the resin column diameter-to-height ratio is 1:10. First elute wit...

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Abstract

The invention relates to an application of arctiin to preparation of medicines for treating the gout. The application of the arctiin in the field of preparing medicines for treating the gout is effectively achieved. According to the preparation of the arctiin, fructus arctii is crushed into rough powder, then soaked in ethyl alcohol and subjected to reflux extraction, the ethyl alcohol is recycled in a filtrate decompression mode until the smell of the ethyl alcohol is removed, a concentrated solution is obtained through concentration, and the concentrated solution is dispersed into dispersion liquid after being added with distilled water; the dispersion liquid is arranged on macroporous adsorption resin, elution is carried out through distilled water, and water liquid is removed; elution is carried out through ethyl alcohol with the volume concentration of 10%, and ethyl alcohol eluant with the volume concentration of 10% is removed; finally, elution is carried out through ethyl alcohol with the volume concentration of 75%, ethyl alcohol eluant with the volume concentration of 75% is collected, the ethyl alcohol is recycled in a decompression mode, drying and crushing are carried out at 60 DEG C, and the arctiin is obtained. The arctiin has the function of lowering uric acid and is effectively used for preparing the medicines for treating the gout, and the application of the arctiin in the field of preparing medicines for treating the gout is realized.

Description

technical field [0001] The invention relates to medicine, in particular to the application of arctiin in medicine for treating gout. Background technique [0002] Gout is a metabolic disease caused by abnormal purine metabolism leading to increased uric acid synthesis. When the renal function is abnormal, the uric acid level will also increase due to the decrease of the uric acid clearance rate of the kidney. Plasma is saturated with uric acid, resulting in the deposition of monosodium urate crystals in the relatively poorly vascular tissue surrounding the distal joint. The appearance of such crystals can lead to acute inflammatory synovitis of monoarticular or polyarticular joints. Gout is more common in men, and the hallux is the most common affected area, with 50% to 70% of initial attacks occurring here. Ninety percent of people with gout will develop involvement of the first metatarsophalangeal joint at some point in their lives. Other areas of the foot that may be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P19/06
Inventor 苗明三白明苗艳艳
Owner HENAN UNIV OF CHINESE MEDICINE
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