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Regeneration aid for bone defects

A technology for forming parts and bones, applied in coatings, medical science, prostheses, etc., can solve the problems of osteoblast growth, lack of environment for cell growth, and inability to ensure nutrient supply.

Inactive Publication Date: 2014-11-05
安东尼·阿莱克斯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that some of these materials will be absorbed quickly, so the purpose of filling or building cannot be achieved until the obstacle is completely absorbed
Although other materials are absorbed more slowly, their outer layer cannot support the growth of osteoblasts, because the barrier stays for too long, so there is no nutrient for osteoblasts to grow
[0004] For example, the forming part mentioned in DE102005060761A1 is a known and familiar embodiment. Although this forming part has the absorption time suitable for bone growth, the disadvantage is that the light passing through the forming part cannot ensure sufficient nutrient supply, and There is also a lack of an environment conducive to cell growth in the area of ​​the form

Method used

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  • Regeneration aid for bone defects
  • Regeneration aid for bone defects

Examples

Experimental program
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Effect test

Embodiment 1

[0059] Toxicity test of abrasive material according to this invention

[0060] The biological response of mammalian animal cells (mouse fibroblast cells L929) compared with the abrasive material according to this invention has been studied. The above-mentioned abrasive material is in a medium (MEM) with 10% fetal bovine serum (0.2 g / ml), and then extract at 37+ / -1℃ for 24+ / -2 hours. The positive and negative tests are prepared in the same way. The medium of L929 cells cultured in a 96-well plate for more than 24+ / -2 hours will be replaced by a total of six replicate extracts, and the cells will be incubated at 37+ / -1℃ 24 to 26 hours. In contrast with the extract, the cell's ability to develop can be measured by measuring the absorption capacity of a certain red neutral pigment. When the pigment is attached to the cell, it is actively being incorporated into the living cell. The number of viable cells will be restricted to the pigment density determined by brightness measuremen...

Embodiment 2

[0062] Regeneration defects caused by the use of aragonite-based (uncoated and 5% collagen coating) bone substitute materials alone and combined with 25% autologous bone

[0063] The function of the tested bone substitutes is to fill or make up for bone defects and damages that cannot be solved by the body's own regenerative ability alone, and as a filling material when undergoing reconstruction surgery, bone tumors or implantation aids, such as: Before the dentist transplant.

[0064] Aragonite-based bone substitute materials will be tested in a so-called "critical-size-defekt" mode for their osteogenic ability, the time course of bone construction, and the time course of material decline to be able to Comply with its statement about mineralization content and its time course. The experimental structure is to use 24 livestock pigs. A total of eight frontal bones with bone defects with a diameter of 1 cm and a height of 1 cm were implanted in each animal. The 3, 7, 14, 21, 30, 5...

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Abstract

The invention relates to a molded part for supporting bone regeneration, in particular the regeneration of a jawbone or jawbone section in a mammal, preferably a human, wherein the molded part is suitable for applying to the jawbone and has a coating having a composition comprising at least one collagen, a granular material, and hyaluronic acid or a hyaluronic acid derivative. The invention further relates to a granular material that can be used in the coating, to a method for producing the granular material, and to the use of the molded part.

Description

Technical field [0001] This invention relates to a shaped part to assist bone reformation. Background technique [0002] There are various medical applications and it is desirable to see that the bone material of human or animal patients can be re-formed on its own. As everyone knows, osteoblasts will try to grow into the cavity. This knowledge has been used in dentistry, for example, when the mandible is partially damaged due to periodontitis. [0003] It is known that the cavity required for the effective growth of the mandibles of humans or animals can be formed through an obstacle or a shaped part or shaped body. In this regard, there are known several materials that can be used as obstacles or used to form obstacles, which can be filled Defects of bones or reconstruction of jaw height and / or width, especially in dentistry. The disadvantage of this method is that some of these materials will be absorbed quickly, so the purpose of filling or construction cannot be achieved be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/24A61L27/58A61L27/36
CPCA61L27/58A61L27/34A61L2430/02A61L27/365A61L27/3608A61L27/3604A61L31/10A61L31/148C08L5/08A61L27/025A61L27/12
Inventor 安东尼·阿莱克斯
Owner 安东尼·阿莱克斯
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