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Pharmaceutical composition for treating internal haemorrhage and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of insufficient drug effect, difficult to cure fundamentally, discomfort and the like, and achieve a remarkable effect of promoting coagulation.

Active Publication Date: 2014-10-29
石柱土家族自治县八龙农业开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compression and packing are commonly used clinically to stop bleeding, but this method of stopping bleeding is not very convenient and effective
[0003] Among the hemostatic agents, there are many kinds of preparations, such as Zhixuemin, Vitamin K, Anluoxue, Gongxuening, etc. These agents are conventional or adjuvant therapy drugs, and they are highly versatile, but their efficacy is not obvious enough.
Longer course of treatment and slower curative effect. When the patient's condition is mild, the curative effect can be obtained. When the patient's condition is severe, it is difficult to obtain the effect of fundamental treatment.
Certain western medicines synthesized from chemical substances have a certain therapeutic effect, but western medicines often have relatively large toxic and side effects, can stimulate stomach discomfort, and are more expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Preparation of Alcoholic Extract of Clove Clove Leaf

[0014] Put 2kg of dried clove leaves in a round-bottomed flask, use 20L of 90% (v / v) ethanol and 65% (v / v) ethanol to reflux extract twice, each time for 4 hours, and pour out the alcoholic extract. Combine the 4 extracts, filter, recover ethanol and continue to concentrate to a thick paste, dry under reduced pressure at 70°C, pulverize into fine powder, and pass through a 100-mesh sieve to obtain the ethanol extract of Clove tomentosa leaves.

Embodiment 2

[0015] Example 2 Preparation of Alcoholic Extract of Clove Clove Leaf

[0016] Put 1 kg of dry clove leaves in a round bottom flask, and use 13 L of 85% (v / v) ethanol and 60% (v / v) ethanol to reflux extract twice, each time for 4 hours, and pour out the alcoholic extract. Combine 4 extracts, filter, recover ethanol and continue to concentrate into a thick paste, dry under reduced pressure at 70°C, pulverize into fine powder, pass through a 100-mesh sieve, and obtain the ethanol extract of Clove cloves leaves.

Embodiment 3

[0017] Example 3 Experiment of recalcification time in mouse plasma

[0018] 36 SPF grade NIH mice, with a body weight of 18-22g, were randomly divided into 3 groups, half male and half male, respectively control group (15mL / kg normal saline), low and high dose groups ( Administer the ethanol extract of Clove tomentosa leaves prepared in Example 1 of the present invention, the dosages are 65 and 130 mg / kg respectively), and intragastric administration, 1 time / d, for 7 consecutive days. One hour after administration on the seventh day, the eyeballs were removed to obtain 1 mL of blood, which was put into a centrifuge tube added with sodium citrate solution, centrifuged at 3000 r / min for 10 min, and the plasma was separated for later use. Take 0.1mL of the upper plasma layer into a test tube, put it in a 37°C water bath and incubate for 2min, then add 0.1mL of 0.25mol / L calcium chloride solution; After 1min, slowly tilt the test tube once every 15s. Record the time required fr...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating internal haemorrhage and application thereof. The composition is prepared from active ingredients and auxiliary materials, wherein the active ingredients are pilose leptodermis leaf alcohol extracts. The pharmaceutical composition is obvious in hemostatic and coagulating effects, can be used for severe refractory functional uterine bleeding, alimentary tract hemorrhage and internal haemorrhage diseases and also can be used for treating various hemorrhage syndromes which are not obvious in effects of conventional hemostatics.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating internal bleeding and its application. Background technique [0002] Blood is an important substance in the human body. In any hemorrhage, if the bleeding is not stopped effectively in time, the blood will be wasted, resulting in weakness of the body and even life-threatening. Therefore, the application of hemostatic drugs is of great significance. Bleeding is divided into two types: external bleeding and internal bleeding. Blood flowing from the wound to the outside is called external bleeding, which is common in knife cuts, stab wounds, bullet wounds, and crush wounds. If there is no wound on the skin, blood will flow from the ruptured blood vessel to the tissue, organ or body cavity, which is called internal bleeding. The causes of internal bleeding are far more complicated than external bleeding, and the treatment is al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P7/04
Inventor 李健
Owner 石柱土家族自治县八龙农业开发有限公司
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