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Elevated platform for detecting animal anxiety and application method thereof

A platform, animal technology, applied in the direction of psychological devices, etc.

Active Publication Date: 2014-10-29
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the platform and test method have not been reported at home and abroad

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  • Elevated platform for detecting animal anxiety and application method thereof
  • Elevated platform for detecting animal anxiety and application method thereof
  • Elevated platform for detecting animal anxiety and application method thereof

Examples

Experimental program
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Effect test

specific Embodiment approach 2

[0019] Testing Anxiety Levels in Genetically Modified Mice Using an Elevated Platform

[0020] 1. Materials

[0021] Wild-type C57 / BL6 mice, APP transgenic mice (Tg2576, 12 months old) and Cpne5+ / - mice (6 months old) were bred by the Experimental Animal Center of the Academy of Military Medical Sciences. The elevated platform (diameter 45cm) was designed by Ding Xuefeng and commissioned by the Instrument Factory of the Academy of Military Medical Sciences. Open field (40cm X 40cm) and elevated plus maze were purchased from Shanghai Xinruan Information Technology Co., Ltd., China. Any-maze software was purchased from American Stoelting Company.

[0022] 2. Method

[0023] We divided animals into three groups, wild group (WT), APP group and Cpne5+ / - group. Open field experiment, elevated plus maze experiment and elevated platform experiment were carried out respectively. Linear correlation analysis was used to analyze the correlation between the time animals spent in the o...

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Abstract

The invention relates to a novel elevated circular platform for detecting animal anxiety and an application method thereof. An anxiety model is prepared by utilizing the mental conflict between the fear for high altitude and the exploration instinct of animals. According to the sizes of the animals, the circular platform with the certain diameter is prepared and placed at the corresponding height, the radius of the platform is divided into a plurality of equal parts, and therefore the platform is divided into a plurality of continuous areas. The safety is sequentially reduced from the circle center to the periphery and forms continuous distribution. After the animals are placed in the central area, the standing time of the animals in each area within the specific time is analyzed, the animals with the lower anxiety level will explore for a longer time in the area with the low safety, and the animals with the high anxiety level will explore for a longer time in the area with the high safety. The result obtained by testing the platform through the genetically modified animals shows that the elevated platform and the method are more sensitive in the aspect of testing the animal anxiety level compared with a classical elevated plus maze, operation is easier and more convenient, and the influence on the animal stress level is smaller.

Description

technical field [0001] The present invention relates to an elevated platform for detecting the anxiety level of animals and its application method. Background technique [0002] At present, the most classic method for testing animal anxiety is the elevated plus maze, which mainly uses the animal's exploration instinct for the external environment and the psychological conflict formed by the fear of heights to test the animal's anxiety level. As shown in Figure 1: The elevated plus maze has two symmetrical open arms and two symmetrical closed arms, which are 60-100cm above the ground. The closed arms have three sides with a height of 30cm-50cm, while the open arms only retain 0.5cm , so security is highest in the closed arm and lowest in the open arm. The criss-crossed area is the starting position of the animal, where the animal is placed. During a fixed test time (3-5 min), animals with low anxiety levels spend more time in the open arm than in the closed arm. Conversely,...

Claims

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Application Information

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IPC IPC(8): A61B5/16
Inventor 丁学锋赵永岐范明朱玲玲刘淑红赵彤
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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