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Coral extract, extraction method and use thereof, and coral extract skin care product

An extract, coral technology, applied in the field of coral extract, can solve problems such as accelerated wound healing

Inactive Publication Date: 2014-10-15
UNI PRESIDENT BIOTECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In recent years, the research on soft corals is still very active. For example, many active briarane-type diterpenes have been found in the soft corals of the genus Briareum. Coral Coral (Briareum excavatum) is cultivated artificially in the laboratory, but so far there is no literature data or patent record that can obtain extracts from Coral Coral that can inhibit tyrosinase activity, accelerate wound healing and anti-inflammation product or purified compound

Method used

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  • Coral extract, extraction method and use thereof, and coral extract skin care product
  • Coral extract, extraction method and use thereof, and coral extract skin care product
  • Coral extract, extraction method and use thereof, and coral extract skin care product

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preparation example 1

[0055] Preparation Example 1: Extracting Coral Coral with Organic Solvent

[0056] The biological sample Briareum excavatum skin soft coral (1021.49g, wet weight) cultured in a large amount in 0.6 tons of aquaculture tank is carried out freeze-drying, and the dried coral tissue is ground (to obtain dry weight 417.75g), then with organic solvent methanol / The mixture ratio of dichloromethane (1:1) was extracted at room temperature, and after repeated extractions until the added organic solvent became clear, the primary extract of the organic layer was obtained. The primary extract was filtered and then concentrated under reduced pressure. The obtained crude extract was partitioned and extracted with water and ethyl acetate, and the crude extract of the ethyl acetate layer (15.75 g) was obtained after partitioned extraction and concentrated under reduced pressure. After the following separation process, BP2 (2.44g, accounting for about 15.5% of the crude extract) and BP3 (5.6g, ...

preparation example 2

[0057] Preparation Example 2: Crude Extract Separation Process

[0058] see figure 1 , the ethyl acetate layer was initially separated by column chromatography, the filler used was silica gel (Merck, 230-400mesh), and the mixed solvent of n-hexane / ethyl acetate and ethyl acetate / methanol was used as the eluting solvent The gradient extraction of liquid is divided into seven fractions, and the extraction conditions of each fraction are as follows:

[0059] Partition 1 (BP1): Hexane:EtOAC (n-hexane: ethyl acetate) 99:1 to 93:7.

[0060] Partition 2 (BP2): Hexane:EtOAC (n-hexane:ethyl acetate) 90:10~70:30.

[0061] Partition 3 (BP3): Hexane:EtOAC (n-hexane:ethyl acetate) 60:40~50:50.

[0062] Partition 4 (BP4): Hexane:EtOAC (n-hexane:ethyl acetate) 40:60~20:80.

[0063] Partition 5 (BP5): Hexane:EtOAC (n-hexane:ethyl acetate) 10:90~0:100.

[0064] Partition 6 (BP6): EtOAC:MeOH (ethyl acetate:methanol) 90:10~50:50.

[0065] Partition 7 (BP7): EtOAC:MeOH (ethyl acetate:methan...

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Abstract

A coral extract for skin whitening, moisture retention, elasticity improvement, anti-inflammation and occlusion of wounds and its extracting method is provided. The coral extract is extracted from Briareum excavatum. The extracting method comprises: extracting with organic solvents, partitioning with water and ethyl acetate and separating via column chromatography. The coral extract can be applied in the field of skin whitening, moisture retention, elasticity improvement, anti-inflammation and occlusion of wounds.

Description

technical field [0001] The present invention relates to a coral extract, extraction method and application, especially to a kind of soft coral (Briareum excavatum). Inflammatory cell infiltration and control of wound area. Background technique [0002] Due to the particularity of the marine ecological environment, the biosynthetic pathways and enzyme reaction systems of secondary metabolites produced by marine organisms are significantly different from those of terrestrial organisms, resulting in marine organisms often able to produce some novel chemical structures and diverse biological activities. Marine secondary metabolites with completely different structural characteristics from terrestrial organisms. [0003] Coral belongs to the coelenterate phylum, and there are more than 9,000 species. It is one of the most common organisms in the ocean, accounting for about 22.4% of marine species, and is a marine biological resource that can be used in large quantities. Soft co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K8/98A61Q19/00A61Q19/02A61P17/16A61P17/02A61P29/00
CPCA61Q19/007A61K8/987A61K35/614A61Q19/02A61Q19/00A61P17/02A61P17/16A61P29/00
Inventor 宋秉钧王维贤温志宏温依珊周泰延郑银彬郭智杰
Owner UNI PRESIDENT BIOTECH
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