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Composition and combination of bmdbm photostabilizers and sunscreens

A technology of butylmethoxydibenzoylmethane and ethylhexyloxyphenolmethoxyphenyltriazine, which can be used in drug combinations, preparations for skin care, active ingredients of heterocyclic compounds, etc., can solve cross-allergies, Contact eczema and other problems, to achieve the effect of good absorption and response

Inactive Publication Date: 2014-10-01
PIERRE FABRE DERMO COSMETIQUE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, octocrylene has the drawback of being a powerful allergen causing contact eczema in children and cross-sensitivity with ketoprofen

Method used

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  • Composition and combination of bmdbm photostabilizers and sunscreens
  • Composition and combination of bmdbm photostabilizers and sunscreens
  • Composition and combination of bmdbm photostabilizers and sunscreens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0098] In Vitro Method for Assessing Overall UV and UVA Photostability

[0099] A) material

[0100] -UV spectrophotometer:

[0101] The spectrophotometer measures the spectral transmittance through the panel with and without a layer of sunscreen composition on the surface.

[0102] The spectrophotometer should allow measurements between 290nm and 400nm. In order to reduce the variability between measurement readings and to compensate for the lack of uniformity of the product layer, it is recommended that the reading area of ​​the site is at least 0.5cm 2 .

[0103] The spectrophotometer used for these measurements was UV-1000S or 2000S.

[0104] -plate:

[0105] A panel is the material on which the sunscreen composition is applied. The material must be UV transparent, non-fluorescent, photostable and inert with respect to the compound of the composition being tested. For this solution, polymethylmethacrylate (PMMA) sheets proved ideal.

[0106] -UV source:

[0107]...

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Abstract

The present invention concerns a composition containing a photostabilized combination of Butyl Methoxydibenzoylmethane (BMDBM), Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine (BEMT), and Methylene Bis- Benzotriazolyl Tetramethylbutylphenol (MBBT) wherein: ( i) - the BEMT / BMDBM mass ratio is greater than or equal to 1 and preferably greater than or equal to 1.5; (ii) - the content of BMDBM is comprised between 1% and 5% by weight with regard to the total weight of the composition; (iii) - the quantity of MBBT is comprised between 3% and 7% by weight with regard to the total weight of the composition, said combination containing no octocrylene, PABA or ethylhexyl methoxycinnamate, and a pharmaceutically or cosmetically acceptable excipient.

Description

technical field [0001] The present invention relates to a combination of photostable sunscreens for butylmethoxydibenzoylmethane (BMDBM). Background technique [0002] Protection against UVA (320-400nm) must substantially limit the damage associated with prolonged exposure that can lead to changes in the skin, acceleration of photoaging, loss of skin elasticity, and the like. [0003] First, review the nomenclature and abbreviations of the main filters involved in the scope of the present invention: [0004] - Butylmethoxydibenzoylmethane (BMDBM) = Avobenzone = CAS registration number: 70356-09-1, the filter is under the DSM trademark Sales, [0005] -2,4-bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine=bis-ethyl Hexyloxyphenol methoxyphenyl triazine (BEMT) = Bemotrizinol = CAS registration number: 187393-00-6, the filter is BASF trademark Sales, [0006] -2,2'-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-phenol=methy...

Claims

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Application Information

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IPC IPC(8): A61K8/35A61K8/49A61Q17/04A61K31/53A61K31/4192A61K31/192A61K31/12
CPCA61K2800/30A61K31/4192A61K8/4966A61K31/53A61Q17/04A61K8/496A61K8/35A61K31/12A61P17/00A61P17/16A61K2300/00A61K8/29A61K8/37A61K31/192A61K8/40A61K8/42A61K8/49
Inventor V·佩里耶H·德罗米尼
Owner PIERRE FABRE DERMO COSMETIQUE CORP
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