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Joint-moving simulation test system with biological culture function

A technology of biological culture and joint movement, applied in the direction of biomass post-treatment, biomass pretreatment, biochemical cleaning device, etc., can solve the problems of cartilage performance limitations, achieve the effect of maintaining tissue activity and prolonging the test time

Inactive Publication Date: 2014-09-10
XI AN JIAOTONG UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, the existing joint simulators can only simulate the kinematic environment of natural joints, so the research on cartilage performance is very limited.

Method used

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  • Joint-moving simulation test system with biological culture function
  • Joint-moving simulation test system with biological culture function
  • Joint-moving simulation test system with biological culture function

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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with specific embodiments.

[0026] see figure 1 , the present invention includes a joint simulator 1 and a biological culture circulation system; the biological culture circulation system includes a culture chamber 5, a peristaltic pump 7, an off-site sterilized glass fermenter 8 and a liquid storage tank 11 connected in sequence, the culture chamber 5 and the peristaltic pump 7, between the peristaltic pump 7 and the off-site sterilized glass fermenter 8, between the off-site sterilized glass fermenter 8 and the liquid storage tank 11, and between the liquid storage tank 11 and the culture chamber 5 through the silicone tube 6 Communication, the inlet and outlet of the liquid storage tank 11 are provided with shut-off valves 9 .

[0027] see Figure 2-4 , the culture chamber 5 is made up of a transparent upper chamber 13 and a transparent lower chamber 14 that can be communicated together...

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Abstract

The invention discloses a joint-moving simulation test system with a biological culture function, which comprises a joint simulator and a biological culture circulating system, wherein the biological culture circulating system comprises a culture cavity, a dislocated sterilized glass fermentation tank and a liquid storage tank which are sequentially communicated, the culture cavity is composed of an upper cavity and a lower cavity which are communicated together, the upper cavity is communicated with the dislocated sterilized glass fermentation tank, and the lower cavity is connected with an inlet of the liquid storage tank; the upper cavity is connected with a horizontal axis of the joint simulator, and the lower cavity is connected with a longitudinal axis of the joint simulator. According to the joint-moving simulation test system disclosed by the invention, the joint simulator can realize the moving control on the culture cavity, and the dislocated sterilized glass fermentation tank can realize the control on the oxygen, carbon dioxide, pH value and temperature of culture liquid in the circulating system. The joint-moving simulation test system disclosed by the invention not only can carry out in-vitro culture on tissue engineered cartilages, but also can efficiently carry out an in-vitro friction and wear performance evaluation test on active joint cartilages.

Description

technical field [0001] The invention relates to a motion simulation test system, in particular to a joint motion simulation test system with biological cultivation function. Background technique [0002] Tissue engineered cartilage has been developed so far. Although there are many experimental research results and a small amount of clinical application, both the function after culture and the long-term effect after implantation are unsatisfactory. How to improve the function of tissue engineered cartilage and how to evaluate the degree of its function before it can be implanted are the focus of attention now. An important factor in tissue engineered cartilage culture is mechanical stimulation. A large number of studies have shown that appropriate mechanical stimulation can increase the expression of cartilage matrix components such as collagen and polysaccharide protein, thereby improving the performance of tissue engineered cartilage. So far, the mechanical stimuli used ...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/38C12M1/36
CPCC12M21/08C12M23/34C12M23/58C12M29/18C12M41/12C12M41/26C12M41/32
Inventor 王玲朱祝山朱锦宇刘亚雄李涤尘靳忠民
Owner XI AN JIAOTONG UNIV
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