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Cefodizime sodium medicine and preparation method thereof

A kind of technology of cefodizime sodium and cefodizime

Active Publication Date: 2014-09-10
LIVZON PHARM GRP INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the long-term production practice, the inventors found that the cefodizime sodium prepared by CN101723958 has: the particles are relatively small and powdery; the static electricity is large, the fluidity is not good, and it is difficult to pack when making reagents; and ethanol Disadvantages such as large residue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Slowly add 11.2 g of sodium isooctanoate into a 95% ethanol solution (60 ml) that is three times its mass, add 5% hydrochloric acid, adjust the pH between 6.0-6.5, stir until sodium isooctanoate dissolves, and prepare sodium isooctanoate solution 15g of cefodizime acid and 95% ethanol are mixed, then the temperature is lowered to 5°C, and 5g of triethylamine, 0.05g of benzophenone hydrazone, and 0.15g of heavy Sodium sulfite, until the cefodizime acid is completely dissolved, keep the temperature at 5°C, add activated carbon to the solution for decolorization, and prepare the cefodizime acid solution; add the sodium isooctanoate solution to the decolorized cefodizime acid solution, add 5% hydrochloric acid, adjust the pH between 6.5-7.0, stir to obtain the ethanol solution of cefodizime sodium crystals; carry out suction filtration to obtain the filter cake of cefodizime sodium, wash the filter cake with absolute ethanol for 15 minutes, and drain the filtrate. Then wash...

Embodiment 2

[0027] Slowly add 11.2 g of sodium isooctanoate into 95% ethanol solution (80 ml) that is 4 times its mass, add 5% hydrochloric acid, adjust the pH between 6.0-6.5, stir until sodium isooctanoate dissolves, and prepare sodium isooctanoate solution 15g of cefodizime acid and 95% ethanol are mixed, then the temperature is lowered to 5°C, and 5g of triethylamine, 0.05g of benzophenone hydrazone, and 0.15g of heavy Sodium sulfite, until the cefodizime acid is completely dissolved, keep the temperature at 5°C, add activated carbon to the solution for decolorization, and prepare the cefodizime acid solution; add the sodium isooctanoate solution to the decolorized cefodizime acid solution, add 5% hydrochloric acid, adjust the pH between 6.5-7.0, stir to obtain the ethanol solution of cefodizime sodium crystals; carry out suction filtration to obtain the filter cake of cefodizime sodium, wash the filter cake with absolute ethanol for 15 minutes, and drain the filtrate. Then wash the f...

Embodiment 3

[0029] Slowly add 11.2 g of sodium isooctanoate into 95% ethanol solution (100 ml) that is 5 times its mass, add 5% hydrochloric acid, adjust the pH between 6.0-6.5, stir until sodium isooctanoate dissolves, and prepare sodium isooctanoate solution 15g of cefodizime acid and 95% ethanol are mixed, then the temperature is lowered to 5°C, and 5g of triethylamine, 0.05g of benzophenone hydrazone, and 0.15g of heavy Sodium sulfite, until the cefodizime acid is completely dissolved, keep the temperature at 5°C, add activated carbon to the solution for decolorization, and prepare the cefodizime acid solution; add the sodium isooctanoate solution to the decolorized cefodizime acid solution, add 5% hydrochloric acid, adjust the pH between 6.5-7.0, stir to obtain the ethanol solution of cefodizime sodium crystals; carry out suction filtration to obtain the filter cake of cefodizime sodium, wash the filter cake with absolute ethanol for 15 minutes, and drain the filtrate. Then wash the ...

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Abstract

The invention relates to a cefodizime sodium medicine and a preparation method thereof and provides a method of preparing cefodizime. The method comprises the following steps: a, first, dissolving sodium iso-octoate in an ethanol solution, and adding a small amount of hydrochloric acid till the pH of the solution is 6.0-6.5 to obtain the ethanol solution of sodium iso-octoate; b, at normal temperature, sequentially mixing ethanol, cefodizime acid, benzophenone hydrazone, sodium metabisulfite and triethylamine, and stirring till cefodizime acid is dissolved to obtain a cefodizime acid solution; c, decoloring the obtained cefodizime acid solution, then, mixing the decolored cefodizime acid solution with the ethanol solution of sodium iso-octoate obtained in the step a, stirring, and adding a small amount of hydrochloric acid till the pH of the solution is 6.5-7.0 to obtain the ethanol solution of cefodizime sodium crystals; d, carrying out suction filtering on the obtained ethanol solution of cefodizime sodium crystals in the step c, and washing the filter cakes by anhydrous ethanol and acetone to obtain a cefodizime sodium wet material; e, drying the cefodizime sodium wet material till the water content is within 3.5%.

Description

technical field [0001] The invention relates to cefodizime sodium medicine and a preparation method thereof. Background technique [0002] Cefodizime sodium, also known as cefodizime, was invented by Hoechst in Germany and is the world's first third-generation cephalosporin with immune-enhancing function; English product name = Modivid, Chinese product name: Modiwei, English chemical name: Cefodizime. Cefodizime can enhance the immune response, and it has been shown in animal models and in vitro and in vivo studies that the drug can activate macrophages and increase their phagocytic activity and bactericidal rate. In vivo, cefodizime prolongs the survival of infected animals, including those infected with drug-resistant bacteria or experimentally immunocompromised. The boosting effect of the drug on the immune system was also observed in most patients. [0003] Cefodizime sodium is a third-generation parenteral cephalosporin. Cefodizime sodium has a high affinity to prot...

Claims

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Application Information

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IPC IPC(8): C07D501/36C07D501/04
CPCC07D501/04C07D501/36
Inventor 莫德欢张鹏肖鸿孔祥生
Owner LIVZON PHARM GRP INC
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