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Novel compound extracted from nardostachys chinensis as well as preparation method and application thereof

A compound and extract technology, applied in the field of new compounds and their preparation, can solve the problems of less research on the chemical constituents of Gansong, and achieve the effects of precise pharmacological action mechanism, shortening action potential, and protecting myocardial cell damage.

Active Publication Date: 2014-09-03
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many chemical constituents of nard pine, but there are relatively few studies on the chemical constituents of nard pine

Method used

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  • Novel compound extracted from nardostachys chinensis as well as preparation method and application thereof
  • Novel compound extracted from nardostachys chinensis as well as preparation method and application thereof
  • Novel compound extracted from nardostachys chinensis as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Structural formula is the concrete preparation method of the compound of a and b as follows:

[0097] A, take by weighing 10kg of dried roots and rhizomes of Pinus saponifera plants of the genus Pinus Patinae, coarsely pulverize them and extract them twice under reflux with 60% ethanol, each time for 2 hours, concentrate under reduced pressure to an extract, and obtain the total extract ;

[0098] B. Separation of the total extract by macroporous adsorption resin HP-20 column chromatography, Φ14×120 cm, retention volume 12L, elution flow rate 80mL / min, respectively with water, 30% ethanol, 50% ethanol, 70% ethanol , 95% ethanol for gradient elution, and the 70% ethanol elution site was chromatographically separated by silica gel column I. The specification of silica gel column I was 10×48 cm, 200 mesh silica gel, and chloroform-methanol system gradient elution was used (100:0, 99:1,95:5,9:1,8:2,0:100), the retention volume is 3.75L, four retention volumes are eluted fo...

Embodiment 2

[0104] Structural formula is the concrete preparation method of the compound of a and b as follows:

[0105] A, take by weighing 10kg of dry roots and rhizomes of Pinus saponifera plant Pinus saponifera, coarsely pulverize them and extract them twice under reflux with 70% ethanol, each time for 2 hours, concentrate under reduced pressure to an extract, and obtain the total extract ;

[0106] B. Separation of the total extract by macroporous adsorption resin HP-20 column chromatography, Φ14×120 cm, retention volume 12L, elution flow rate 100mL / min, respectively with water, 30% ethanol, 50% ethanol, 70% ethanol , 95% ethanol for gradient elution, and the 70% ethanol elution site was chromatographically separated by silica gel column I. The specification of silica gel column I was 10×48 cm, 300 mesh silica gel, and chloroform-methanol system gradient elution was used (100:0, 99:1,95:5,9:1,8:2,0:100), the retention volume is 3.75L, four retention volumes are eluted for each gradi...

Embodiment 3

[0112] Structural formula is the concrete preparation method of the compound of a and b as follows:

[0113] A, take by weighing 10kg of dry roots and rhizomes of Pinus saponifera plant Pinus saponifera, coarsely pulverize them and extract them twice under reflux with 70% ethanol, each time for 2 hours, concentrate under reduced pressure to an extract, and obtain the total extract ;

[0114] B. Separation of the total extract by macroporous adsorption resin HP-20 column chromatography, Φ12×100 cm, retention volume 10L, elution flow rate 100mL / min, respectively with water, 30% ethanol, 50% ethanol, 70% ethanol , 95% ethanol for gradient elution, and the 70% ethanol elution site was chromatographically separated by silica gel column I. The specification of silica gel column I was 12×60 cm, 300 mesh silica gel, and chloroform-methanol system gradient elution was used (100:0, 99:1, 95:5, 9:1, 8:2, 0:100), the retention volume is 4L, each gradient elution has four retention volume...

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Abstract

The invention discloses a novel compound extracted from nardostachys chinensis as well as a preparation method and application thereof. The novel compound comprises compounds with structural formulae a and b and is obtained by extracting and purifying dry roots and rhizomes of the nardostachys chinensis; the compounds with the structural formulae a and b are capable of treating myocardial cell injury and inhibiting calcium rise of myocardial cells; the compound with the structural formula a is capable of reducing action potential of the myocardial cells.

Description

technical field [0001] The invention belongs to the field of organic compounds, and in particular relates to new compounds and their preparation methods and uses. Background technique [0002] Gansong is the root and rhizome of Gansong and broad-leaf Gansong. Gansong is a perennial herb, born in alpine grasslands at an altitude of 3,500 to 4,500 meters, distributed in Gansu, Qinghai, Sichuan, and northwest Yunnan; broad-leaved Gansong grows in alpine grasslands or sparse forests above 3,000 meters, distributed in Sichuan, Yunnan, Tibet and other places. When the stems and leaves wither in late autumn and early winter, dig out the roots, shake off the sand, do not wash, remove the residual stems and fibrous roots, and dry in the shade or in the sun. The rhizome of Gansong is slightly conical, more curved, and 5-18cm long. The rhizome is short, with stem and leaf residues at the upper end, in the form of long and narrow membranous sheets or fibers; the outer layer is dark b...

Claims

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Application Information

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IPC IPC(8): C07C49/643C07C45/78A61K31/122A61P9/00
CPCC07C45/78C07C49/643C07C2603/08C07C2603/12
Inventor 戴毅刘明莉姚新生吴以岭王宏涛
Owner SHIJIAZHUANG YILING PHARMA
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