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Preparation method for tiamulin micro-capsule preparation

A tiamulin preparation technology, applied in the field of preparation of tiamulin microcapsule preparations, can solve the problems of low bioavailability, poor palatability, strong irritation, etc., and achieve increased feed intake, long-lasting, good stability effect

Active Publication Date: 2014-07-30
SINOPHARM YANGZHOU VAC BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By using microcapsule technology, the present invention can solve the deficiencies of poor palatability, strong irritation, weak stability, and low bioavailability of existing tiamulin oral preparations.

Method used

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  • Preparation method for tiamulin micro-capsule preparation
  • Preparation method for tiamulin micro-capsule preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add the original tiamulin powder into the hydrogenated vegetable oil containing 5% magnesium stearate and 1.3% triglycerol monostearate in a mass ratio of 1:1, high-speed emulsification and shear stirring for 45 minutes , the temperature is controlled at 80°C; the obtained material is transferred to 4 times the volume of an aqueous solution containing 0.5% chitosan, 0.2% pectin and 1.5% Tween 80 by mass percentage, the temperature is controlled at 80°C, and stirred for 30 minutes After cooling down, keep stirring until the tiamulin microcapsules in the solution are completely precipitated; stop stirring, filter and dehydrate the above-mentioned materials through a 200-mesh sieve, and make tiamulin microcapsule preparations after low-temperature vacuum drying. The particle size of the microcapsules ranges from 150 μm to 250 μm, the recovery rate (the ratio of the total weight of the microcapsules to the total weight of the feed) is 94.4%, and the encapsulation efficiency ...

Embodiment 2

[0028] Add tiamulin original powder into hydrogenated vegetable oil containing 10% magnesium stearate and 1% triglycerol monostearate in mass ratio of 1:8, high-speed emulsification and shear stirring for 15 minutes , the temperature is controlled at 80°C; the obtained material is transferred to 4 times the volume of an aqueous solution containing 0.5% chitosan, 0.2% pectin and 1.5% Tween 80 by mass percentage, the temperature is controlled at 80°C, and stirred for 30 minutes After cooling down, keep stirring until the tiamulin microcapsules in the solution are completely precipitated; stop stirring, filter and dehydrate the above-mentioned materials through a 200-mesh sieve, and make tiamulin microcapsule preparations after low-temperature vacuum drying. The particle size of the microcapsules ranged from 300 μm to 500 μm, the recovery rate was 93.7%, the encapsulation efficiency was 98.7%, and the drug loading was 10.3%.

Embodiment 3

[0030] Add the original tiamulin powder into the hydrogenated vegetable oil containing 2.5% magnesium stearate and 2% triglycerol monostearate in a mass ratio of 2:1, high-speed emulsification and shear stirring for 60 minutes , the temperature is controlled at 70°C; the obtained material is transferred to 4 times the volume of an aqueous solution containing 1% chitosan, 0.2% pectin and 1% Tween 80 in mass percentage, the temperature is controlled at 70°C, and stirred for 30 minutes After cooling down, keep stirring until the tiamulin microcapsules in the solution are completely precipitated; stop stirring, filter and dehydrate the above-mentioned materials through a 200-mesh sieve, and make tiamulin microcapsule preparations after low-temperature vacuum drying. The particle size of the microcapsules ranged from 100 μm to 150 μm, the recovery rate was 96.8%, the encapsulation efficiency was 96.4%, and the drug loading was 63.4%.

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Abstract

The invention discloses a preparation method for a tiamulin micro-capsule preparation, which belongs to the field of veterinary medicine preparations. The tiamulin micro-capsule preparation is obtained by adding tiamulin raw powder medicine in hydrogenated vegetable oil containing magnesium stearate and tripolyglycerol monostearate, and adequately and uniformly stirring, then adding the materials above in an aqueous solution containing chitosan, pectin and tween-80, and carrying out cooling treatment. The preparation method is scientific, simple and practicable, high in medicine encapsulation rate and recovery rate, adjustable in particle size according to the particle size of the raw material medicine and the dosage of a coating wall material. Clinical tests prove that the preparation method disclosed by the invention is capable of improving palatability and good in slow-release action, and provides an efficient tiamulin micro-capsule preparation for veterinary clinically.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation method of tiamulin microcapsule preparation. Background technique [0002] Tiamulin is a special diterpene antibiotic for livestock and poultry, and it is one of the top ten veterinary antibiotics in the world. The drug has the function of preventing and treating chicken chronic respiratory disease, swine mycoplasma pneumonia, actinomyces pleuropneumonia and treponemal dysentery. At the same time, it can promote the growth of livestock and poultry and improve the utilization rate of feed when used in low doses. It is widely used in the breeding industry. Applications. [0003] Although tiamulin has played an extremely important role in livestock and poultry production, there are still some deficiencies: (1) Tiamulin tastes bitter, and it will affect palatability after oral administration, resulting in poor feed intake or drinking water. (2) Tiamulin is...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K31/22A61K47/44A61K47/26A61K47/36A61P31/04A61P11/00
Inventor 龚建森许明俞燕周守长徐步刘学贤窦新红童海兵邹剑敏
Owner SINOPHARM YANGZHOU VAC BIOLOGICAL ENG CO LTD
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