Burn composition, preparation method and application thereof

A composition and drug technology, applied in the direction of drug combination, effective ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve problems such as poor curative effect and untargeted therapeutic drugs

Active Publication Date: 2016-08-17
高建
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the treatment of burn sepsis is mostly comprehensive therapy, such as fluid resuscitation, anti-infection, cortisol hormone drugs, vasoconstrictor drugs, etc., but the curative effect is not good. Foreign epidemiological data show that the mortality rate is 30%~ Between 70%, especially for burns and sepsis with intestinal barrier damage There is currently no targeted therapy

Method used

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  • Burn composition, preparation method and application thereof
  • Burn composition, preparation method and application thereof
  • Burn composition, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: burn composition preparation

[0023] No. 1 ointment: take 500g each of rhubarb, burnet, gallnut, calamine, red stone, and yellow wax, 7.5kg of sesame oil, and 50g of borneol;

[0024] No. 2 ointment: take 500g each of rhubarb, burnet, gallnut, calamine, red stone, and yellow wax, 6kg of sesame oil, and 100g of borneol;

[0025] No. 3 ointment: take 500g each of rhubarb, burnet, gallnut, calamine, red stone, and yellow wax, 9kg of sesame oil, and 75g of borneol;

[0026] Preparation steps:

[0027] ① Grind rhubarb, burnet, gallnut, calamine and red stone into medicinal powder and mix;

[0028] ② Heat the sesame oil to boiling;

[0029] ③ Add the yellow wax to the boiling sesame oil, stir until the yellow wax is completely melted, and stop heating;

[0030] ④ Gradually add the premixed medicinal powder to the sesame oil, stir and mix until the medicinal powder is evenly distributed;

[0031] ⑤ After cooling, add ice flakes, stir and mix well, that is. ...

Embodiment 2

[0032] Example 2: Animal research on burn composition treating intestinal barrier damage in burn sepsis

[0033] We used the No. 1 burn composition prepared in Example 1 to conduct animal experiments. The object of the animal experiment is selected as the "second hit" model rat of burn sepsis. Experiments used included:

[0034] a The experimental mice were 48 SD rats;

[0035] b reagent selection TNF-a kit; IL-1β kit; HMGB1 kit:; DAO kit; D-LA kit; AST kit; ALT kit:; IL-10 kit; HMGB1:; TGF- β1:;β-actin:;Super Signaling West Femto kit;

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Abstract

The invention relates to the field of a traditional Chinese medicine composition, and discloses a burn composition as well as a preparation method and application thereof. The burn composition disclosed by the invention comprises rheum officinale, sanguisorba officinalis, gallnut, calamine, red halloysite, beeswax, sesame oil and borneol. The burn composition is capable of reducing the contents of D-LA, DAO, fluorescein isothiocyanate marked glucan (FITC-D), AST and ALT in plasma after second-hit of sepsis after burn injury and the level of TNF-alpha and IL-1beta, upwards regulating the content of IL-10 and the expression of TGF-beta1 and Occludin-1 and downwards lowering the level of intestine HMGB1 (High Mobility Group Box 1), and therefore, the burn composition has relatively good prospect in preparation of medicines for preventing and treating burn sepsis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a burn composition, its preparation method and its application, especially the application in the prevention and treatment of burn sepsis intestinal barrier damage. Background technique [0002] Burns can cause damage to local and remote organs. Therefore, the treatment of burns should not only treat wound injuries, but also protect multiple organs throughout the body. At present, the main cause of death of severely burned patients is the occurrence of sepsis after burns, and further development can lead to multiple organ dysfunction (MODS) or even multiple organ failure (MOF), which is the main cause of death in ICU wards. Therefore, prevention and treatment of burn sepsis should be focused on severely burned patients. [0003] In the pathogenesis of burn sepsis, enterogenic infection is currently receiving extensive attention. The intestinal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/739A61P17/02A61P31/04A61K31/045A61K33/30A61K35/64A61K33/26A61K35/644
Inventor 高建苏涌
Owner 高建
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