Salt of oxysophorcarpine derivative

A technology for oxidizing sophocarpine and compounds, applied in organic chemistry, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as adverse reactions, unsatisfactory drug treatment effects, and drug resistance, and achieve practical The effect of therapeutic activity

Inactive Publication Date: 2014-07-09
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the treatment of mycoplasma, chlamydia, and fungal infections, these existing drugs are likely to cause many and severe adverse reactions, and some produce drug resistance. not ideal

Method used

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  • Salt of oxysophorcarpine derivative
  • Salt of oxysophorcarpine derivative
  • Salt of oxysophorcarpine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Oxidized Sophocarpine Fumarate

[0048] The compound oxysophocarpine 2.62 g (0.01 mol) and fumaric acid 1.17 g (0.01 mol) were dissolved in 75 ml of boiling ethanol. The hot solution is filtered through diatomaceous earth, then slowly cooled under gentle stirring, and left to stand for several hours at a temperature of 0-5°C to precipitate oxysophocarpine fumarate crystals, and to filter out oxysophocarpine fumarate Salt crystals were washed with ethanol and dried under vacuum at 50°C to obtain 3.78 g of product.

Embodiment 2

[0050] Oxidized Sophocarpine Fumarate

[0051] 2.62 g of compound oxysophocarpine fumarate and 1.17 g of fumaric acid were stirred in 90 ml of refluxing ethanol until all the solids were dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Standing for several hours in a temperature environment of 0-5°C, oxidized sophocarpine fumarate crystals are precipitated, filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 3.78 g of product.

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Abstract

The invention relates to oxysophocarpine fumarate or its pharmaceutically acceptable solvates, and an application of the oxysophocarpine fumarate or its pharmaceutically acceptable solvates in the preparation of medicines for treating mycoplasma, chlamydia and fungal infection.

Description

field of invention [0001] The invention relates to the field of medicinal chemistry, in particular, the invention relates to organic acid salts of oxysophocarpine derivatives and their pharmaceutical application. Background technique [0002] For now, although there are many kinds of drugs for the treatment of mycoplasma, chlamydia, and fungal infections, these existing drugs are likely to cause many and severe adverse reactions, and some produce drug resistance. Not ideal. Chinese patent application publication number CN101336958A describes some active compounds for treating mycoplasma, chlamydia and fungal infections. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stability and solid form stability. Some of these ...

Claims

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Application Information

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IPC IPC(8): C07D471/22A61K31/4375A61P31/04A61P31/10A61P31/12
CPCC07D471/22
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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