Salt of sophocarpine derivative

A technology of sophocarpine and a drug, which is applied to the organic acid salt of a sophocarpine derivative and its pharmaceutical application field, can solve the problems of adverse reactions, drug resistance, unsatisfactory drug treatment effect, etc., and achieves practical therapeutic activity. Effect

Inactive Publication Date: 2014-07-09
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the treatment of mycoplasma, chlamydia, and fungal infections, these existing drugs are likely to cause many and severe adverse reactions, and some produce drug resistance. not ideal

Method used

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  • Salt of sophocarpine derivative
  • Salt of sophocarpine derivative
  • Salt of sophocarpine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Sophocarpine Fumarate

[0048] The compound sophocarpine 2.46 g (0.01 mol) and fumaric acid 1.17 g (0.01 mol) were dissolved in 75 ml of boiling ethanol. The hot solution is filtered through diatomaceous earth, then slowly cooled under gentle stirring, and left to stand for several hours in a temperature environment of 0-5°C, sophocarpine fumarate crystals are precipitated, and sophocarpine fumarate is filtered out The crystals were washed with ethanol and dried under vacuum at 50°C to yield 3.61 g of product.

Embodiment 2

[0050] Sophocarpine Fumarate

[0051] 2.46 g of the compound sophocarpine fumarate and 1.17 g of fumaric acid were stirred in 90 ml of refluxing ethanol until all the solids were dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Stand for several hours at a temperature of 0-5°C, sophocarpine fumarate crystals are precipitated, filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 3.61 g product.

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Abstract

The invention relates to sophocarpine fumarate or its pharmaceutically acceptable solvates, and an application of the sophocarpine fumarate or its pharmaceutically acceptable solvates in the preparation of medicines for treating mycoplasma, chlamydia and fungal infection.

Description

field of invention [0001] The invention relates to the field of medicinal chemistry, in particular, the invention relates to organic acid salts of sophocarpine derivatives and their pharmaceutical application. Background technique [0002] For now, although there are many kinds of drugs for the treatment of mycoplasma, chlamydia, and fungal infections, these existing drugs are likely to cause many and severe adverse reactions, and some produce drug resistance. Not ideal. Chinese patent application publication number CN101336958A describes some active compounds for treating mycoplasma, chlamydia and fungal infections. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stability and solid form stability. Some of these com...

Claims

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Application Information

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IPC IPC(8): C07D471/22A61K31/4375A61P31/00A61P31/10
CPCC07D471/22
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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