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A device for preparing an animal model of stress gastric mucosal injury

A technology of gastric mucosal injury and animal models, which is applied in the fields of equipment for restraining animals, medical science, veterinary scrubbers, etc., to achieve the effects of reducing model-making differences, improving model-making efficiency, and reducing unnecessary differences

Inactive Publication Date: 2015-12-02
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there is no standardized device for preparing animal models of stress gastric mucosal injury at home and abroad.

Method used

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  • A device for preparing an animal model of stress gastric mucosal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Such as figure 1 As shown, the device for preparing the stress gastric mucosal injury model of the present invention mainly consists of a constant temperature water bath, a rat cage lifter 2, a rat cage, a heating rod 8, a temperature sensor 9, a control circuit 10, a control circuit operating power supply 11, The heating rod power switch 12 and the heating rod power supply 13 are composed;

[0026] The water bath housing 1 of the constant temperature water bath is provided with a water tank, and a squirrel cage lifter 2, a heating rod 8, and a temperature sensor 9 are also installed in the water bath housing 1; one side of the water bath housing 1 is provided with an electrical box, Control circuit 10, control circuit working power supply 11, heating rod power switch 12 and heating rod power supply 13 are all installed in the electrical box; 9. Connect the control circuit 10 and the working power supply 11 of the control circuit in sequence, and the control circuit 10...

Embodiment 2

[0034] Example 2 Preparation process of animal model of stress gastric mucosal injury (rat is used as model animal)

[0035] 200-250g SD rats were anesthetized quickly with ether and placed in the cage, so that the head of the rat was inserted into the upper narrow part of the left and right splints, and the tightness of the left and right splints and the height of the bottom plate were adjusted to fix the rat's body; The mouse cage was fixed on the mouse cage lifter, and the screw of the mouse cage lifter was manually adjusted to adjust the water application depth of the rats, and the rats were immersed in the water for 4 hours to prepare a rat model of stress gastric mucosal injury.

Embodiment 3

[0037] The degree of gastric mucosal injury was measured by gastric mucosal injury index.

[0038] The sum of the lengths of each lesion in the whole stomach is the damage index (expressed in mm): 1 point for damage ≤ 1 mm (including erosion points); 2 points for 1 mm 4mm is 5 points; the damage index is doubled for damage width>2mm.

[0039] After using the device according to the present invention to make models according to the method described in the rat model making process of the above-mentioned Example 2, the damage index increased significantly, from 0 in normal rats to 65 ± 65 ± in injury model rats. 7.6.

[0040] The results of the above examples show that this device is a standardized, normalized, simple in structure, convenient to use, and good effect device for preparing animal models of stress gastric mucosal injury; Flexible control of the watering depth of experimental animals improves the success rate of modeling. At the same time, it can strictly control the...

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Abstract

The invention belongs to the technical field of animal disease model preparation, and relates to a device for preparing an irritability gastric mucosal lesion animal model. The device mainly consists of a constant-temperature water bath kettle, a mouse cage lifter, a mouse cage, a heating rod, a temperature sensor, a control circuit, a control circuit working power supply, a heating rod power supply switch and a heating rod power supply, wherein a water tank is arranged in the shell of the water bath kettle; the mouse cage lifter, the heating rod and the temperature sensor are also installed in the shell of the water bath kettle; one side of the shell of the water bath kettle is provided with an electrical cabinet; the control circuit, the control circuit working power supply, the heating rod power supply switch and the heating rod power supply switch are all arranged in the electrical cabinet. A use result indicates that the device has the advantages of simple structure, convenience in use, good effect and reasonable construction, the experiment animal water spreading depth can be flexibly controlled, the molding success rate is improved, the stability degree in the experiment animal molding process can be strictly controlled, and the molding difference caused by an external factor is reduced.

Description

technical field [0001] The invention belongs to the technical field of animal model preparation, and relates to a device for preparing a stress gastric mucosal injury model; the device can be used for making gastric mucosal injury models of various experimental animals. Background technique [0002] At present, the preparation of animal disease models is a necessary research method for scientific research in the field of biomedicine; the animal disease models should have the characteristics of high sensitivity and repeatability, and should also be standardized and normalized. At present, gastric mucosal injury disease is the most common and common digestive system disease in the world. Therefore, the establishment of stress-induced gastric mucosal injury animal model is of great significance for the research on the pathogenesis and treatment strategies of gastric mucosal injury. [0003] So far, there is no standardized device for preparing animal models of stress gastric mu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D11/00A61D3/00
Inventor 杜东书曹银祥邓振旭朱大年王锦夏春梅
Owner FUDAN UNIV
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