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Three microRNAs (ribose nucleic acids) from tea tree and application thereof

A technology of tea tree and nucleotide sequence, applied in the field of microRNA and its application, can solve the problem of extremely low detection abundance

Active Publication Date: 2014-05-28
ZHEJIANG ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since sodium periodate is a strong oxidizing agent, it can oxidize the 2' and 3' free hydroxyl groups of animal-derived miRNAs, resulting in the animal-derived miRNAs not being detected or detected in extremely low abundance during miRNA sequencing and qPCR

Method used

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  • Three microRNAs (ribose nucleic acids) from tea tree and application thereof
  • Three microRNAs (ribose nucleic acids) from tea tree and application thereof
  • Three microRNAs (ribose nucleic acids) from tea tree and application thereof

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Abstract

The invention discloses three microRNAs (ribose nucleic acids) from a tea tree and application thereof, belongs to the technical field of drugs, and provides three microRNA sequences and microRNA precursor sequences from the tea three as well as application thereof in treatment of tumor, diabetes mellitus, fatty liver and respiratory diseases.

Description

technical field The invention belongs to the technical field of medicines, and specifically relates to three microRNAs derived from tea trees and applications thereof. Background technique microRNA (miRNA) is a "star molecule" that has been studied more in recent years. Noncoding RNAs consisting of 18–25 nucleotides are first transcribed from the nuclear genome to form primary miRNAs (pri-miRNAs) with capped structures and polyadenosine tails. Pri-miRNA is treated with nuclease Drosha to form about 70 nt precursor miRNA (pre-miRNA) containing the stem link, which is then cleaved into mature miRNA by nuclease. miRNA binds to the 3'UTR sequence of target gene mRNA through incomplete base pairing, guides the silencing complex (RNA-induced silencing complex, RISC) to degrade mRNA or inhibits the translation of mRNA, thereby regulating gene expression. One miRNA can bind multiple target genes, and one mRNA can also be co-regulated by multiple miRNAs. This complex regulatory ne...

Claims

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Application Information

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IPC IPC(8): A61K48/00C12N15/11A61P35/00A61P3/10A61P1/16A61P11/00A61P31/00
Inventor 余陈欢应华忠钟宇森金晓音吕宇方杰
Owner ZHEJIANG ACAD OF MEDICAL SCI
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