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Containing thiadiazole or oxadiazole derivatives and their application in the prevention and treatment of agricultural plant diseases

A technology of thiadiazole and oxadiazole, which is applied in the chemical, application, biocide and other directions for biological control, can solve problems such as unreported agricultural activity, and achieves simple structure, low production cost, and preparation process. simple effect

Inactive Publication Date: 2016-01-06
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2-mercapto-5-substituent-1,3,4-thia(oxa)diazole derivatives have received more attention in medical applications due to their excellent physiological activities, but their agricultural activities have not been reported yet

Method used

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  • Containing thiadiazole or oxadiazole derivatives and their application in the prevention and treatment of agricultural plant diseases
  • Containing thiadiazole or oxadiazole derivatives and their application in the prevention and treatment of agricultural plant diseases
  • Containing thiadiazole or oxadiazole derivatives and their application in the prevention and treatment of agricultural plant diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Determination of Indoor Inhibition of Bacterial Disease Pathogen Activity of Some Compounds

[0045] (1) Determination of the indoor activity of some compounds against rice bacterial blight

[0046] Put the rice bacterial blight pathogen in M210 (enzymatically hydrolyzed casein: 8g, sucrose: 5g, yeast extract: 4g, K 2 HPO 4 : 3g, MgSO 4 ·7H 2O: 0.3g, agar: 15g, secondary water: 1L, pH=7.0) Streak on the solid medium, culture at 28°C until a single colony grows. Pick a single colony of rice bacterial blight pathogen on M210 solid medium to M210 liquid medium (enzymatically hydrolyzed casein: 8g, sucrose: 5g, yeast extract: 4g, K 2 HPO 4 : 3g, MgSO 4 ·7H 2 O: 0.3g, secondary water: 1L, pH=7.0), cultured on a constant temperature shaker at 28°C and 180rpm until the logarithmic phase of growth was set aside.

[0047] The synthesized compound and the control drug were respectively configured at a concentration of 200 and 100 mu g / mL toxic M210 liquid medi...

Embodiment 2

[0061] Embodiment 2: Determination of the activity of some compounds inhibiting fungal pathogens of crops indoors

[0062] The antibacterial activity of the compounds was determined by the in vitro growth rate method. Heat potato dextrose agar medium (PDA medium: 200g potato, 20g agar, 20g glucose, 1000mL distilled water) to a molten state (40-60°C), pour 10mL of liquid medicine (10 times the final concentration of liquid medicine) into 90mL of PDA for culture Shake well, pour evenly into a petri dish with a diameter of 9cm, place it horizontally, and wait for it to cool and solidify. Use a puncher to punch a 4mm-diameter fungus dish at the edge of the fresh pathogenic bacteria colony that has been cultured for 4 days, put the fungus dish upside down in the center of the PDA plate containing the drug, and then place it in a constant temperature and humidity incubator at 27°C for upside-down culture, and wait for the blank control When the colony grows to nearly two-thirds of ...

Embodiment 3

[0067] Embodiment three: highly active compound toxicity regression equation and inhibitory medium concentration (EC 50 ) value determination

[0068] (1) Regression equation and EC of compound toxicity to rice bacterial blight pathogen 50 Determination of value

[0069] The synthetic compound and the control agent were respectively configured into 5 corresponding concentrations of toxic M210 liquid medium, 5 mL was taken in a test tube, and the OD value of the toxic sterile liquid medium was measured with a microplate reader (OD 595 ), adding 40 mu L contains the M210 liquid medium containing the pathogenic bacteria of Xanthomonas oryzae, then cultivated it on a constant temperature shaker at 28°C and 180rpm for 24~48h, and measured the OD values ​​(OD 595 ). In addition, the OD value of the toxic and sterile M210 liquid medium containing the control drug and the OD value of the bacterial solution of each concentration after 24 to 48 hours were measured, and the OD value ...

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Abstract

The invention discloses a class of 2-mercapto-5-substituent-1,3,4-thia(oxa)diazole derivatives for preventing and treating bacterial and fungal diseases of crops. Due to their excellent physiological activity, these derivatives are It has received more attention in medical aspects, but its agricultural activity has not been reported yet. This study shows that these compounds can effectively inhibit bacterial disease pathogens such as rice bacterial blight, rice bacterial stripe, tobacco bacterial wilt, tomato bacterial wilt, and wheat head blight, potato late blight, and apple rot. , Pepper Fusarium Wilt, Cucumber Botrytis, Rapeseed Sclerotinia and other fungal disease pathogens. At the same time, 2-mercapto-5-substituent-1,3,4-thia(oxa)diazole derivatives are used to prevent and treat bacterial and fungal diseases of crops, with simple structure, simple preparation process, low production cost and broad application prospects . Has the following general formula.

Description

technical field [0001] The invention relates to chemical industry and pesticide, and the specific technology is the application of a class of 1,3,4-thia(oxa)diazole derivatives to prevent and control bacterial and fungal diseases of crops. Background technique [0002] As a large agricultural country, my country plays an extremely important role in ensuring agricultural production. Aiming at the current problems of major agricultural bacterial and fungal diseases, scientifically and efficiently discovering green pesticide candidates that are safe and have potential market vitality is an important task in the basic research of new pesticide creation in my country. Lead discovery is the key to realizing innovative green chemical pesticides. It is extremely urgent and important to design, optimize and synthesize several types of pesticide lead structures, and to develop new low-toxicity, low-residue, safe green chemical pesticides. [0003] Plant diseases caused by pathogenic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D285/125C07D271/113C07D413/04C07D417/04A01N43/824A01P1/00A01P3/00
CPCA01N43/82C07D271/113C07D285/125C07D413/04C07D417/04
Inventor 宋宝安李培杨松胡德禹薛伟金林红徐维明贺鸣施利杨霞史庆才吴芳
Owner GUIZHOU UNIV
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