Building method of mouse stomach cancer model
A gastric cancer model, a technology for establishing a method, applied in the field of experiments, can solve the problems of error, lack of immune system in immunodeficient mice, etc., and achieve the effect of inducing chronic stress and good stability
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[0022] 1. Gastric cancer-inducing compound: MNU (n-methyl-n-nitrosourea, N-methyl-Nnitrosourea). Administration route: dissolved in drinking water of mice. Dose: 240ppm.
[0023] 2. Stress mold: 50ml centrifuge tube (poke 5-10 small holes)
[0024] 3. Steps:
[0025] Take a 4-week-old C57BL / 6 mouse, put the mouse into a 50ml centrifuge tube (poke 5-10 small holes), restrain its activities, put one mouse in each centrifuge tube, 6 hours a day, for 28 days It is a stress cycle, and each stress cycle is separated by 5 days, and there are 3 stress cycles in total. At the same time of stress, the mice were given drinking water containing MNU, and the administration was given one week apart, and normal drinking water was given between the administrations, for a total of 5 weeks. At the same time, the MNU group that only gave the mice drinking water containing MNU without stress treatment and the stress group that only received stress treatment according to the above method were ...
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