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Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof

A technology of hyperlipidemia and composition, applied in the field of traditional Chinese medicine, can solve the problems of low content of active ingredients, incomplete absorption, inconvenient carrying, etc.

Inactive Publication Date: 2014-04-09
NANCHANG JISHUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the early research and development time, limited by the research level at that time, most of the medicinal materials were crude products that were only crudely extracted, with low content of active ingredients, large dosage, incomplete absorption, low bioavailability, and drug efficacy. Slow, inconvenient to carry, etc.

Method used

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  • Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof
  • Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof
  • Traditional Chinese medicine composition for treating hyperlipidemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] 1. (1) Add 4 times of 60% ethanol to the crushed lotus leaf, adjust the pH to 12.0, reflux and extract twice at 75°C for 2 hours each time, and collect the extract for later use;

[0087] (2) Add 4 times of 85% ethanol to the residue of the lotus leaf medicinal material obtained in (1), adjust the pH to 3.0, reflux and extract at 75°C for 3 times, each time for 2 hours, and collect the extract for later use;

[0088](3) Centrifuge and filter the supernatant of the extract in (1), and reclaim ethanol by distillation under reduced pressure, adjust the pH to 7.0, then centrifuge and filter, take the supernatant and prepare a 3mg / mL solution, pump Into the AB-8 macroporous resin column for adsorption, the loading volume is 4BV, after gradient elution with pure water, 20% ethanol 2BV each, and elution with 70% ethanol, the eluate is collected, and the ethanol is recovered under reduced pressure. Evaporate and concentrate at a temperature of 0.06MPa-0.09MPa and 65°C-85°C to o...

Embodiment 2

[0097] 320g of lotus leaf extract, 160g of salvia miltiorrhiza extract, 240g of hawthorn extract, 160g of salt psoralen extract and 4g of senna leaf extract prepared in the 1-5 steps of embodiment 1 are mixed, add sugar powder, starch, Low-substituted hydroxypropyl cellulose and other auxiliary materials are used in appropriate amounts to prepare 1000 g of granules.

Embodiment 3

[0099] Mix 160g of lotus leaf extract, 20g of salvia miltiorrhiza extract, 120g of hawthorn extract, 20g of salt psoralen extract, and 6g of senna leaf extract prepared in steps 1-5 of Example 1, add starch, low-substituted hydroxyl Appropriate amount of auxiliary materials such as propyl cellulose, made into granules, and packed into 1000 capsules.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating hyperlipidemia. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine extracts in parts by weight: 40-80 parts of lotus leaf extracts, 10-20 parts of salvia miltiorrhiza extracts, 30-60 parts of hawthorn extracts, 10-20 parts of malaytea scurfpea fruit or salt-processed malaytea scurfpea fruit extracts and 1-3 parts of folium sennae extracts. The invention also discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has good efficacy.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition for treating hyperlipidemia and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique: [0002] Atherosclerosis caused by hyperlipidemia is the main cause of coronary heart disease, hypertension and vascular disease. The situation of dyslipidemia in our country is severe, which seriously threatens the health of our people. The total prevalence of dyslipidemia in adults aged 18 and over in my country is 18.6%, that is, the number of patients with dyslipidemia has reached 160 million; and the incidence of dyslipidemia is tending to be younger, and the prevalence of middle-aged people is similar to that of the elderly. Therefore, it is very important to do a good job in the early prevention and treatment of dyslipidemia and to study drugs that have good effects in regulating blood lipids and have less toxic side effects. [0003] In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61P3/06
Inventor 何凯南曾英姿周万辉安少凯张丹赵磊陈武
Owner NANCHANG JISHUN PHARMA CO LTD
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