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Bacterial strains belonging to the genus bifidobacterium for use in the treatment of hypercholesterolaemia

A technology for hypercholesterolemia and Bifidobacterium bifidum, which is applied in the direction of bacterial medical raw materials, preparations and applications for in vivo experiments, and can solve uncontrollable problems

Inactive Publication Date: 2014-03-19
PROBIOTICAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This uncontrollable and unnecessary production of cholesterol represents a serious disadvantage

Method used

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  • Bacterial strains belonging to the genus bifidobacterium for use in the treatment of hypercholesterolaemia
  • Bacterial strains belonging to the genus bifidobacterium for use in the treatment of hypercholesterolaemia
  • Bacterial strains belonging to the genus bifidobacterium for use in the treatment of hypercholesterolaemia

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0059] Experimental part

[0060] The applicant has carried out intensive research activities for the selection of bacterial strains.

[0061] "In vivo" studies

[0062] A total of 32 rats were housed in cages. After a few days of adaptation to the diet (T0), all rats began to receive the same 100% hypercholesterolemia diet (100% hypercholesterolemizing diet). After 15 days of this diet (T15), the rats were randomly divided into 4 subgroups (8 rats per subgroup). Rats were initially treated differentially from T15 to T45. These treatments continued for 30 days until sacrifice (T45):

[0063] group 1 : 30% high cholesterol diet and Lactobacillus reuteri (Lactobacillus reuteri) NCIMB701359 (Kandler et al; 1982), 1 × 10 9 / day (reference). This strain is known to have the ability to lower cholesterol levels (ref).

[0064] group 2 : 30% high cholesterol diet and probiotic mixture [Bifidobacterium lactis MB2409DSM23733 (0.33×10 9 / day), Bifidobacterium breve MB113DS...

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Abstract

The present invention relates to selected bacterial strains belonging to the genus Bifidobacterium for use in the treatment of hypercholesterolaemia. In particular, the present invention relates to a food composition or supplement product or medical device or pharmaceutical composition comprising said bacterial strains in association with sterols or phytosterols and / or stanols or phytostanols and / or glucomannan and / or konjac gum and / or prebiotic fibres and / or fermented red rice and / or betaglucans from oats, oat bran, barley, barley bran and / or aloe arborescens gel in lyophilized form.

Description

technical field [0001] The present invention relates to selected strains of bacteria belonging to the genus Bifidobacterium for use in the treatment of hypercholesterolemia. In particular, the present invention relates to a compound containing cholesterol or plant cholesterol, and / or stanols (stanols) or plant stanols, and / or glucomannan, and / or konjac gum, and / or prebiotic said bacterial strains in combination with metafibers, and / or fermented red rice, and / or beta-glucan (from oats, oat bran, barley, barley bran), and / or aloe vera gel in freeze-dried form food composition or supplement product or medical device or pharmaceutical composition. Background technique [0002] All cells of the body are known to synthesize cholesterol from acetyl-CoA, but most cholesterol is produced in the peroxisomes of liver cells, which transfer it to the blood for transport throughout the body. [0003] When we talk about "cholesterol" in medicine, we don't mean cholesterol as a chemical p...

Claims

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Application Information

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IPC IPC(8): A61K35/74A23L1/30A61K35/745
CPCA23L1/3002A23L1/308A23L1/053A23L1/3014A61K35/745A23L29/25A23L33/105A23L33/135A23L33/21A61P3/06A61P43/00A23L33/195A61K2121/00
Inventor G·莫格纳G·P·斯特罗兹卢卡·蒙加
Owner PROBIOTICAL
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