Novel synthesized molecules of EBV (Epstein-Barr Virus) consensus DNA (Deoxyribonucleic Acid) sequence and vaccine formed thereby
A DNA sequence and consensus technology, applied in the fields of genetic engineering technology and immunology, can solve the problems of immaturity and limited efficiency of liposome introduction of chemical preparations, etc.
Active Publication Date: 2014-03-12
杭州中晟纳博生物科技有限公司
View PDF0 Cites 2 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
The delivery efficiency of chemical formulations into liposomes is limited, ultrasound and laser methods are still immature
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
example 1
[0020] Example 1: Construction and expression identification of consensus sequences cEBNA1ΔGGA&GR, cLMP1ΔCTAR1&2 and cLMP2 expression vectors.
[0020] Example 1: Construction and expression identification of consensus sequences cEBNA1ΔGGA&GR, cLMP1ΔCTAR1&2 and cLMP2 expression vectors.
example 2
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more PUM
Login to view more Abstract
The invention relates to three synthesized EBV (Epstein-Barr Virus) DNA (Deoxyribonucleic Acid) sequences which respectively encodes three consensus amino acid sequences EBNA1 (Epstein-Barr Nuclear Antigen 1), LMP1 (Latent Membrane Protein 1) and LMP2 (Latent Membrane Protein 2). The three sequences are respectively constructed on expression vector plasmids to express corresponding amino acid sequences. The invention further provides different methods for generating anti-corresponding EBV protein antigen immunoreaction by one or more expression plasmids.
Description
technical field [0001] The present invention relates to the field of genetic engineering technology and immunology technology, in particular to the consensus sequence cloning, codon-optimized expression of EBV virus expression proteins EBNA1, LMP1 and LMP2, and the immune method of injecting and entering mammalian tissue cells to achieve the induction The body's immune response. Generate cellular and humoral immunity against EBV virus infection or clear infected cells or cancerous cells containing EBV virus proteins. Background technique [0002] Epstein-Barr virus (EBV) causes more than 90% of infectious mononucleosis (IM) in developed countries. EBV is usually transmitted through oral secretions and infects B cells in the throat. The initial stage of infection is usually asymptomatic or non-specific symptoms. However, infection in adolescents or young adults can lead to IM, and recent serological studies have shown that 75% of EBV-positive patients can lead to IM. [00...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more Application Information
Patent Timeline
Login to view more Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/38C12N15/85A61K48/00A61P31/22
Inventor 林峰吴炯
Owner 杭州中晟纳博生物科技有限公司
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Try Eureka
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap