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Method for purifying glucosamine hydrochloride mother liquid

A purification method and mother liquor technology, applied in the field of biochemistry, can solve the problems of product loss, simple treatment method, and inability to recover, and achieve the effects of no by-products, high product purity, and little environmental pollution.

Active Publication Date: 2014-03-12
ANHUI JOINTFREE BIO-SCITECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current production process, the treatment method for GAH mother liquor is simple, and there is a large amount of product loss that cannot be recovered
Therefore, the improvement of the output and quality of GAH is greatly limited, and it is not conducive to expanding its application range.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1: the purification method of glucosamine hydrochloride mother liquor

[0066] 1. Add GAH mother liquor (the content of GAH is 48%, the content of glutamic acid is 5.07% (m / v)) and deionized water to adjust the concentration to 15% (m / v), and add sodium hydroxide to adjust the pH value It is 3.22, stirred evenly at room temperature, naturally settled for 3 hours, and vacuum filtered (vacuum degree: -0.1Mpa) to obtain the filtrate (glutamic acid content: not detected);

[0067] 2. Take 5 kg of the filtrate obtained in step 1), and adsorb it through a cation exchange resin with a volume of 1 L at a column speed of 1.0 BV / h. Feed 3.52kg, so that the cation exchange column is saturated, the waste water after adsorption (GAH: 0.54g / 100mL) is recycled, and the cation exchange column is used for standby;

[0068] 3. Rinse the above-mentioned cation exchange resin with deionized water at a column speed of 1.0BV / h. During the rinsing, continuously detect whether ther...

Embodiment 2

[0073] Embodiment 2: the purification method of glucosamine hydrochloride mother liquor

[0074] 1. Add GAH mother liquor (the content of GAH is 34%; the content of glutamic acid is 5.15%) and add distilled water to adjust the concentration to 20% (m / v), add sodium hydroxide to adjust the pH value to 3.5, at room temperature Stir evenly under low pressure, settle naturally for 1.5h, and use vacuum filtration (vacuum degree: -0.1Mpa) to obtain the filtrate (glutamic acid content: not detected);

[0075] 2. Take 5kg of the filtrate obtained in step 1), and pass it through the column at a rate of 2.0BV / h for adsorption through a cation exchange resin with a volume of 1.5L. The adsorption temperature is 28°C, and the outlet pH value is 2.95. Feed 2.18kg to make the cation exchange column saturated, the waste water after adsorption (GAH: 0.39g / 100mL) is recycled, and the cation exchange column is used for standby;

[0076] 3. Rinse the above-mentioned cation exchange resin with de...

Embodiment 3

[0081] Embodiment 3: the purification method of glucosamine hydrochloride mother liquor

[0082] 1. Add GAH mother liquor (the content of GAH is 38%, the content of glutamic acid is 3.95% (m / v)) and add distilled water to adjust the concentration to 10% (m / v), add sodium hydroxide to adjust the pH value 3.0, stir evenly at room temperature, settle naturally for 2 hours, and use vacuum filtration (vacuum degree: -0.08Mpa) to obtain the filtrate (glutamic acid content: not detected).

[0083]2. Take 5kg of the filtrate obtained in step 1). Adsorption is carried out through a cation exchange resin with a volume of 2L at a column passing speed of 2.0BV / h. The adsorption temperature is 35°C and the outlet pH value is 3.18. The waste water (GAH: 0.67g / 100mL) is recycled, and the cation exchange column is used for standby;

[0084] 3. Rinse the above-mentioned cation exchange resin with deionized water at a column passing speed of 2.0BV / h. During rinsing, continuously detect whethe...

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Abstract

The invention relates to a method for purifying a glucosamine hydrochloride mother liquid. The method provided by the invention has the advantages of high extraction ratio, high product purity, no byproduct generation and the like; as adsorbing waste water and washing waste water can be reused, the method low in environmental pollution, and is suitable for industrialized production.

Description

technical field [0001] The invention relates to the technical field of biochemistry. Specifically relates to a purification method of glucosamine hydrochloride mother liquor. Background technique [0002] D-Glucosamine Hydrochloride (GAH for short) is an important derivative prepared from chitin, which has important physiological functions for the human body. It participates in liver and kidney detoxification, plays the role of anti-inflammatory and liver protection; stimulates the growth of bifidobacteria in the intestinal tract of infants; has a good effect on the treatment of rheumatoid arthritis and gastric ulcer diseases; can inhibit the growth of cancer cells, is a synthetic antibiotic and anti-inflammatory The main raw material of cancer drugs; it can also be used in food, cosmetics and feed additives, and has a wide range of uses. Therefore, this product has been highly valued by medicine, industry and researchers all over the world. [0003] my country is a major...

Claims

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Application Information

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IPC IPC(8): C07H5/06C07H1/06
Inventor 李荣杰尚海涛邓远德潘声龙王超王国庆
Owner ANHUI JOINTFREE BIO-SCITECH CO LTD
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