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New compositions for treating neurological disorders

A composition and compound technology, applied in the direction of drug combination, nervous system diseases, neuromuscular system diseases, etc.

Inactive Publication Date: 2014-02-26
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this molecule has limited benefit for most Alzheimer's disease rings as it has only modest symptom-specific effects

Method used

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  • New compositions for treating neurological disorders
  • New compositions for treating neurological disorders
  • New compositions for treating neurological disorders

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Experimental program
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Embodiment Construction

[0236] Animal care and management and experiments were performed in accordance with the guidelines of the Committee for Research and Ethical Issue of the I.A.S.P. (1983).

[0237] A) Treatment of diseases related to Aβ toxicity

[0238] In this series of experiments, candidate combinations have been tested which prevent or reduce human Aβ 1-42 toxic effects. Aβ 1-42is the full length peptide constituting aggregates found in biopsies from human patients afflicted with AD. This effect was determined by various cell types to further document the activity of the combination in in vitro models that exemplify the different physiological features of AD. In vivo studies were also performed in mouse models to confirm this protective effect by evaluating the effect of the combination on: i) the cognitive performance of the animals and ii) the molecular hallmarks of AD (apoptosis induction, oxidative stress induction , induction of inflammatory pathways).

[0239] I. The compounds p...

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Abstract

The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid beta toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.

Description

field of invention [0001] The present invention relates to compositions and methods for treating neurological diseases and disorders. More specifically, the present invention relates to novel combination therapies for such diseases, including Alzheimer's disease and related diseases, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, neuropathy, alcoholism, alcohol withdrawal, Huntington's disease and spinal cord injury. Background of the invention [0002] Alzheimer's disease (AD) is a prototypical cortical dementia characterized by memory deficits attributable to cortical-associated areas involved, as well as speech disorders (language disorders in which speech is impaired and speech comprehension is impaired), dyspraxia ( Inability to coordinate and perform certain purposeful movements and postures without motor or sensory impairment) and agnosia (the ability to recognize objects, people, sounds, shapes, or smells) (1-4). [0003] AD is currently th...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61K31/445A61K31/4709A61K31/48A61K31/495A61K31/64A61P25/28A61K31/28
CPCA61K31/50A61K31/138A61K31/4709A61K31/496A61K31/185A61K31/197A61K31/585A61K31/445A61K31/4985A61K31/44A61K45/06A61K31/64A61K31/42A61K31/48A61K31/137A61K31/495A61K31/423A61K31/28A61P21/00A61P21/02A61P25/00A61P25/04A61P25/14A61P25/16A61P25/28A61P25/32A61P29/00A61P43/00A61K2300/00
Inventor 丹尼尔·科恩伊利娅·丘马科夫谢尔盖·马卡罗奇金伊曼纽尔·瓦若米卡尔·居德
Owner PHARNEXT
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