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A method for preparing soluble yeast glucan

A yeast glucan, soluble technology, used in allergic diseases, drug combinations, etc., can solve problems such as high cost, pollution, and safety hazards

Active Publication Date: 2015-09-09
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical modification mainly increases the solubility of yeast dextran by linking hydrophilic groups, such as phosphorylation, carboxymethylation, and sulfation, but such reactions are usually carried out in organic solvent systems and strong acids. , Strong alkali, not only high cost, serious pollution, but also may cause safety hazards; physical methods are mainly ultrasonic depolymerization and oxidative degradation methods, which increase the solubility of yeast dextran by reducing the molecular weight, but ultrasonic depolymerization can only reduce its molecular weight to a limiting constant value, while oxidative degradation introduces impurities such as oxidants into the dextran

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Preparation of Soluble Yeast Glucan by Mechanochemical Method Scheme 1

[0018] Mix yeast glucan powder and grinding balls (steel balls with a diameter of 3 mm) evenly at a mass ratio of 1:20, and use planetary ball milling to perform mechanochemical treatment, with a power of 900W and a treatment time of 30 minutes. Tap water is passed outside the spherical tank Circulating refrigeration; dissolve the treated yeast glucan in water at a mass ratio of 1:25, and centrifuge at 4000rpm for 20 minutes in a centrifuge to obtain a yeast glucan solution, in which 54% of the yeast glucan is dissolved in Water, 46% yeast glucan is insoluble in water.

Embodiment 2

[0019] Example 2 Preparation of Soluble Yeast Glucan by Mechanochemical Method Scheme 2

[0020] Mix the yeast glucan powder and the grinding ball (ceramic ball with a diameter of 6mm) evenly at a mass ratio of 1:12, and use a planetary ball mill for mechanochemical treatment with a power of 900W and a treatment time of 15 minutes, and tap water is passed outside the spherical tank Circulating refrigeration; dissolve the treated yeast glucan in water at a mass ratio of 1:20, centrifuge at 4000rpm for 20min in a centrifuge to obtain a yeast glucan solution, in which 34% of the yeast glucan is dissolved in Water, 66% of the yeast glucan is insoluble in water; after distilling the solution to volume with water, soluble yeast glucan with a concentration of 8.8g / L is obtained.

Embodiment 3

[0021] Example 3 Preparation of Soluble Yeast Glucan by Mechanochemical Method Scheme 3

[0022] Mix yeast glucan powder and grinding balls (ceramic balls with a diameter of 10mm) evenly at a mass ratio of 1:5, and use planetary ball milling for mechanochemical treatment, with a power of 1200W and a treatment time of 5 minutes, and tap water is passed outside the spherical tank Circulating refrigeration; dissolve the treated yeast glucan in water at a mass ratio of 1:10, centrifuge at 4000 rpm for 20 minutes to obtain a yeast glucan solution, in which 29% of the yeast glucan is dissolved in Water, 71% of the yeast glucan is insoluble in water; after distilling the solution to volume with water, soluble yeast glucan with a concentration of 6.0 g / L is obtained.

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Abstract

The invention discloses a method for preparing soluble yeast glucan. After mixing powdered yeast glucan and grinding balls according to the mass ratio of 1:5~20, the planetary ball mill is used for processing under the condition of power 900~1200W After 5-30 minutes, the obtained yeast glucan was mixed with water at a mass ratio of 1:10-25 to dissolve the yeast glucan, and the insoluble matter was removed by centrifugation to obtain a yeast glucan solution. The method of the invention has the characteristics of simplicity, rapidity, high efficiency and cleanness, and the prepared yeast glucan has better water solubility and excellent immune activity.

Description

Technical field [0001] The present invention involves the field of yeast glucan technology, and especially involves a method of improving the solubility of yeast glucan and preparing soluble yeast polysaccharides. Background technique [0002] Yeast β-D-polysaccharides (referred to as yeast β-glycogen or yeast glycosan) is a good immune response (non-specific immune enhancer).Wound healing, anti -radiation and other physiological effects, but due to its special chemical structure, it is insoluble in water and only soluble in the two -septum maple, which seriously restricts the application of yeast glycosaccharides in the industrial application. [0003] In order to improve the solubility of yeast glycogen, scholars at home and abroad have conducted modification and modification research, including chemical modification and physical methods.The chemical modification method is mainly to increase its solubility by connecting hydrophilic groups on yeast glucan, such as phosphorylatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/02A61P37/04
Inventor 史锋石纪奎李永富
Owner JIANGNAN UNIV
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