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Application of lycojaponicumin A in the preparation of anti-fungal drugs for human body

A technology against human fungi and drugs, which is applied in antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as digestive tract irritation and strong accumulation of toxicity, and achieve outstanding substantive features and human fungal inhibition Active effect

Active Publication Date: 2015-09-09
FENGJIE DONGYANG BUILDING MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of lycojaponicumin A in the preparation of anti-fungal drugs for human body
  • Application of lycojaponicumin A in the preparation of anti-fungal drugs for human body
  • Application of lycojaponicumin A in the preparation of anti-fungal drugs for human body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Lycojaponicumin A tablet involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Lycojaponicumin A capsules involved in the present invention:

[0015] Get 20 grams of compound Lycojaponicumin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Lycojaponicumin A anti-human fungal activity

[0018] Anti-human fungus activity experiment is the method of concentration dilution, each determination is repeated three times, the test pathogens are Trichophyton rubrum, Microsporum lanoides and Trichophyton aureus, and the concentration of bacteria solution is 10 5 individual / mL. The initial concentration of Lycojaponicumin A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the same volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungus culture temperature 28°C respectively, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Lycojaponicumin A against human fungi are shown in Table 1.

[0019] Table 1 Lycojaponicumin A anti-human fung...

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Abstract

The invention discloses application of Lycojaponicumin A in preparation of an anti-human fungus drug and belongs to the field of medicine. The Lycojaponicumin A has good inhabiting effect on trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, so that the Lycojaponicumin A can serve as an anti-human fungus compound and is hopefully applied in preparation of related drugs. The application of the Lycojaponicumin A in the preparation of the anti-human fungus drug is disclosed for the first time. Due to the fact that the skeleton type is a novel skeleton type and the high human fungus inhabiting activity of the Lycojaponicumin A is previously unimagined, the possibility that other compounds give any revelation does not exist, and the Lycojaponicumin A has outstanding substantive characteristics and meanwhile has a remarkable improvement in prevention and curing of human fungus infection obviously.

Description

technical field [0001] The present invention relates to the use of Lycojaponicumin A, in particular to the application of Lycojaponicumin A in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Lycojaponicumin A...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/424A61P31/10
Inventor 江春平王泽正
Owner FENGJIE DONGYANG BUILDING MATERIALS CO LTD
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