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Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof

A technology of intestinal mucosal injury and composition, applied in the field of traditional Chinese medicine, to achieve strong repair effect, improve abdominal pain and diarrhea, and prolong the effect of disease-free survival

Inactive Publication Date: 2013-09-11
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medicine for the treatment of intestinal mucosal damage after colorectal cancer surgery and / or chemotherapy that is made the same as the composition of the present invention.

Method used

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  • Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof
  • Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof
  • Traditional Chinese medicinal composition for treating intestinal mucosa damage and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 Granules

[0032] Weigh raw materials: Codonopsis 100g, Atractylodes macrocephala 200g, Poria cocos 100g, kudzu root 200g, scutellaria baicalensis 50g, berberine 150g, astragalus 100g.

[0033] Add 8 times the amount of water to the above raw material drug, heat and reflux to extract once, each time for 2 hours, filter, combine the extract, concentrate, dry to obtain 180g of dry extract, grind it into fine powder, add conventional preparation excipients, and mix well Granulated, packed into 100 packs of granules. Each contains 1800mg of traditional Chinese medicine composition. Usage: 1 pack each time, 3 times a day, 7 days a week, 4 weeks as a course of treatment.

Embodiment 2

[0034] Example 2 tablet

[0035] Weigh raw materials: Codonopsis 200g, Atractylodes macrocephala 100g, Poria cocos 200g, kudzu root 100g, scutellaria baicalensis 150g, coptis 30g, astragalus 200g.

[0036]Add 15 times the amount of water to the above raw material drug, heat and reflux for extraction twice, each time for 1 hour, filter, combine the extract, concentrate, dry to obtain 182g of dry extract, grind it into fine powder, add conventional preparation excipients, and mix well Granulated, compressed into tablets, tablet weight 600mg. Each tablet contains 440mg of traditional Chinese medicine composition. Usage: 4 tablets each time, 3 times a day, 7 days a week, 4 weeks as a course of treatment.

Embodiment 3

[0037] Embodiment 3 capsules

[0038] Weigh raw materials: Codonopsis 160g, Atractylodes macrocephala 160g, Poria cocos 160g, kudzu root 160g, scutellaria baicalensis 80g, coptis 80g, astragalus 160g.

[0039] Add 10 times the amount of water to the above-mentioned raw material drug, heat and reflux to extract twice, each time for 1 hour, filter, combine the extract, concentrate, dry to obtain 185g of dry extract, grind it into fine powder, add conventional preparation excipients, and mix well Granulate, pack No. 0 capsules, 500mg per capsule. Each capsule contains 450mg of traditional Chinese medicine composition. Usage: 4 capsules each time, 3 times a day, 7 days a week, 4 weeks as a course of treatment.

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicinal composition for treating intestinal mucosa damage after colorectal cancer surgery and (or) chemotherapy and a preparation method and application thereof. The traditional Chinese medicinal composition which is in accordance with the thinking of superior treat before sick in traditional Chinese medicine, adopts the rules of strengthening spleen, clearing heat and detoxifying and is prepared from the traditional Chinese medicines, such as 10 to 20 parts of codonopsis pilosula, 10 to 20 parts of atractylodes, 10 to 20 parts of poria cocos, 10 to 20 parts of stewed radix puerariae, 5 to 15 parts of scutellaria baicalensis, 3 to 15 parts of coptis chinensis and 10 to 20 parts of astragalus membranaceus, disclosed by the invention can be used for the adjuvant therapy of the intestinal mucosa damage after the colorectal cancer surgery and (or) the chemotherapy for a long time and the treatment of spleen deficiency and damp-heat syndrome of colorectal cancer. By the traditional Chinese medicinal composition, the clinical symptoms such as abdominal pain and diarrhea after the surgery and (or) the chemotherapy can be reduced obviously and has the effect of repairing the intestinal mucosa damage, so that the living quality of a patient is improved, the disease-free lifetime of the colorectal cancer is prolonged, and the effect-enhancing and toxicity-reducing effects are very good.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine and relates to a compound Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating intestinal mucosal injury, a preparation method and application thereof. Background technique: [0002] In recent years, the incidence rate of colorectal cancer in my country has ranked third among malignant tumors. At present, surgical resection is the radical treatment for colorectal cancer. However, about 50% of colorectal cancer patients may develop recurrence or metastasis within two years after radical surgery, and 70% of colorectal cancer patients may develop liver and lung metastasis. Metastasis of colorectal cancer is a difficult point in clinical treatment, and it is also one of the main causes of death in patients with colorectal cancer. The high metastasis rate and high mortality rate of colorectal cancer seriously threaten human health. The newly ...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P1/04
Inventor 王文海付晓伶周荣耀朱惠蓉
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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