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Novel glycyrrhizic acid double salt, and preparation and application thereof

A technology of glycyrrhizate and glycyrrhizic acid is applied in the preparation of sugar derivatives, preparations for skin care, medical preparations containing active ingredients, etc. Healing, low solubility, good lipophilicity and moisturizing effect

Active Publication Date: 2013-08-14
NANJING HUASHI NEW MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no relevant report on silver zinc glycyrrhizinate and its preparation and application in the published technical literature

Method used

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  • Novel glycyrrhizic acid double salt, and preparation and application thereof
  • Novel glycyrrhizic acid double salt, and preparation and application thereof
  • Novel glycyrrhizic acid double salt, and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Put 10 grams of glycyrrhizic acid into a 250ml beaker, add 80ml of 20% ethanol solution, heat to 50°C, fully stir to dissolve, heat to 50°C, and keep away from light, mix 2g of silver nitrate solution and 15g of zinc nitrate solution at the same time Add it into the glycyrrhizic acid solution at a flow rate of 5 g / s, and white precipitates appear. After the addition is complete, stir in the dark for 4 hours, age for 4 hours, filter, filter and wash with ice water, and dry at 60°C to obtain licorice Silver Zinc Acid Product C 42 h 59 o 16 AgZn·5H 2 O, the yield is 82.3%..

[0037] Elemental analysis results (%): Ag9.92 (9.98), Zn6.21 (6.0), C46.51 (46.58), H 6.43 (6.38)

[0038] Determination of H by thermal analyzer 2 O%: 8.25

[0039] IR: 3415cm -1 , 1645cm -1 , 1620cm -1 , 1405cm -1

Embodiment 2

[0041] Put 15 grams of sodium glycyrrhizinate into a 500ml beaker, add 100ml of 30% ethanol aqueous solution, heat to 70°C, fully stir and dissolve to form a transparent solution; at the same time, add 50ml of water to each of the other two 250ml beakers, and add 20 grams of zinc nitrate, 1 gram of silver nitrate, heated to 70 ° C, stirred and dissolved, slowly added sodium glycyrrhizinate solution into the silver nitrate solution, and stirred for 3 hours in the dark, then added zinc nitrate solution to it, after adding completely , continue to stir in the dark for 6 hours, age at 40°C for 5 hours, wash with ice water, and dry at 70°C to obtain silver zinc glycyrrhizinate product C 42 h 59 o 16 AgZn·5H 2 O, the yield is 85.1%.

Embodiment 3

[0043] Put 20 grams of potassium glycyrrhizinate into a 500ml beaker, add 200ml of 10% ethanol aqueous solution, heat to 70°C, fully stir and dissolve to form a transparent solution; dissolve 2 grams of silver nitrate in 60ml of water, and dissolve 3 grams of zinc sulfate in Mix potassium glycyrrhizinate solution and silver nitrate solution in 60ml of water at 60°C, and stir for 5 hours in the dark, then add zinc sulfate solution to the mixed solution, continue to stir for 6 hours in the dark, let stand, and filter with ethanol Washing, drying at 70°C to obtain silver zinc glycyrrhizinate product C 42 h 59 o 16 AgZn·5H 2 O, the yield is 71.7%.

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Abstract

The invention belongs to the field of chemical raw materials, and discloses a novel glycyrrhizic acid double salt, and preparation and application thereof. The invention relates to a preparation method of a glycyrrhizic acid double salt, which comprises the following steps: dissolving glycyrrhizic acid or soluble glycyrrhetate thereof in water or a water-ethanol mixed solution, meanwhile, respectively dissolving a soluble silver salt and a soluble zinc salt in water or a water-ethanol mixed solution, and dissolving by stirring at 10-95 DEG C in a dark place; and mixing the three salt solutions to react, thereby obtaining the zinc silver glycyrrhetate white precipitate. In the invention, the glycyrrhizic acid or soluble salt thereof is combined with necessary microelement zinc for the human body and silver ions with broad-spectrum sterilizing effect for the first time; different activity action mechanisms of the glycyrrhizic acid or soluble salt thereof, zinc and silver ions are utilized to perform the functions of diminishing inflammation, killing bacteria, resisting viruses and restoring normal functions of histiocytes; and the glycyrrhizic acid double salt can be used for preparing medicines for diminishing inflammation and killing bacteria on the skin surface, or medicines for promoting restoration of mucous membranes and epithelial tissues as well as wound healing, and can also be used for preparing a washing-type personal nursing system.

Description

technical field [0001] The invention belongs to the field of chemical raw materials, and relates to a novel double salt of glycyrrhizic acid and its preparation and application. Background technique [0002] Glycyrrhizic acid (Glycyrrhizic acid), also known as glycyrrhizin, glycyrrhizin, scientific name (3β, 20β)-20-carboxylic acid-11-oxo-30-n-olean-12-en-3-yl-20 -β-D-glucopyranosyl-α-D-glucopyranuronic acid, the molecular formula is C 42 h 62 o 16 Abbreviated as H 3 G, the structural formula is as follows: [0003] [0004] Glycyrrhizic acid is one of the most important active ingredients in licorice. It has anti-inflammatory, anti-viral, cough-relieving, phlegm-relieving, liver-protecting and detoxifying functions, invigorating the spleen and stomach, promoting the regeneration of mucosal microtubes, improving the maturity of regenerated mucosal tissue and enhancing the immune function of the body. , which widely exists in a variety of leguminous plants, is a very ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/63C07H15/256A61P31/10A61Q5/12A61Q5/02A61K31/704A61Q19/10A61P29/00C07J63/00C07H1/00A61P17/02A61P17/00
Inventor 任欢鱼苏桂珍史鲁秋李华山
Owner NANJING HUASHI NEW MATERIAL
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