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Novel uridine peptide antibiotics and application thereof

A halogen and group technology, applied in the direction of peptides, tripeptide components, tetrapeptide components, etc., can solve the problems of anti-tuberculosis candidates with new structural skeletons since the mid-1970s.

Inactive Publication Date: 2013-07-03
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the mid-1970s, when the RNA polymerase inhibitor rifampicin was successfully used clinically, no drug specifically for TB treatment has been successfully developed in the past 40 years; no anti-tuberculosis candidate with a new structural skeleton has been seen things appear

Method used

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  • Novel uridine peptide antibiotics and application thereof
  • Novel uridine peptide antibiotics and application thereof
  • Novel uridine peptide antibiotics and application thereof

Examples

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Embodiment Construction

[0094] The present invention is further illustrated by specific preparation examples and biological test examples below, but it should be understood that these examples and test examples are only used for more detailed descriptions, and should not be interpreted as being used for any purpose. Form limits the invention.

[0095] The present invention provides general and / or specific descriptions of the materials and test methods used in the tests. While many of the materials and methods of manipulation which are employed for the purposes of the invention are well known in the art, the invention has been described here in as much detail as possible. It will be clear to those skilled in the art that in the following, unless otherwise specified, the materials and operation methods used in the present invention are well known in the art.

[0096] A. Example part

[0097] With reference to the method described in CN 101153052A (ZL 200610141075.7), for example, the fermentation m...

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Abstract

The invention relates to novel uridine peptide antibiotics and application thereof. Particularly, the invention provides a compound with the following formula I or a pharmaceutically acceptable salt or solvent complex thereof, wherein each substituent group is as shown in the specification. The invention further provides a preparation method of the compound with the formula I and application of the compound as a medicament, particularly as an antibacterial agent such as an antituberculous medicament.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a new class of compounds that can be used as bacterial inhibitors, in particular to a class of Sansanmycin-like uridine peptide antibiotics with antibacterial activity and a preparation method thereof, and the use of such compounds as drugs, especially as Use of antibacterial drugs such as anti-tuberculosis drugs. Background technique [0002] Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, and its prevalence has reemerged in recent years. my country is one of the 22 countries with a high burden of TB in the world, with a high prevalence rate and a high rate of drug resistance. According to the statistics of the World Health Organization (WHO), about 550 million people in my country are infected with tuberculosis, of which more than 400,000 are drug-resistant patients. It is one of the countries with the largest number of new tuberc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/037A61K38/06A61K38/07A61P31/04A61P31/06
Inventor 解云英陈汝贤许鸿章俞莹姚恩泰何宁任浩蔡强
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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