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Macronutrient sensitivity

A macroelement and sensitivity technology, applied in the field of identification of macroelement sensitivity of receptors, can solve problems such as difficulty in satisfying satiety

Inactive Publication Date: 2013-06-26
GENETICS INVESTMENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, previous approaches struggled to satisfy satiety, a physiological feedback mechanism that suppresses appetite

Method used

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  • Macronutrient sensitivity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0260] The notebook board (Note board) can be composed of any number of SNPs, the number of SNPs is greater than or equal to 3 for each macroelement sensitivity. For the examples, assume the use of

[0261] 1) A carbohydrate sensitive panel consisting of:

[0262] ■FTO-rs9939609-Metabolism-based surrogate indicator

[0263] ■Glucose metabolism-related dysfunction

[0264] ■TCF7L2-rs7903146-based metabolism surrogate indicator

[0265] ■Glucose metabolism-related dysfunction

[0266] ■G6PC2-rs560887-surrogate based on metabolism

[0267] ■Glucose metabolism-related dysfunction

[0268] as well as

[0269] 2) Lipid Sensitive Plate consisting of:

[0270] ■APOE-rs4420638-surrogate based on metabolism

[0271] ■Lipid metabolism-related dysfunction

[0272] ■PCSK9-rs11206510-surrogate based on metabolism

[0273] ■Lipid metabolism-related dysfunction

[0274] ■APOB-rs693-surrogate based on metabolism

[0275] ■Lipid metabolism-related dysfunction

[0276] The recipient...

Embodiment 2

[0298] Approximately 100 individuals followed the MyGene diet plan. Individuals were stratified into macronutrient-sensitive diet groups based on genotype and monitored on a weekly basis for up to 6 months. Individuals assigned to the macronutrient-sensitive diet group based on genotype experienced an average fat mass loss of approximately 1 kg / week while maintaining muscle mass, and these individuals were then monitored until they reached their target body weight.

[0299]Independent groups of individuals who were double-blind and randomly assigned to a control diet without diet and genotype matching lost an average of 4 kg of body weight over a 4-week period, with most of the weight loss coming from muscle mass (2.4 kg) and fat mass (1.6 kg).

[0300] Importantly, individuals consuming a diet based on a macronutrient sensitivity that is consistent with individuals reporting a feeling of fullness (i.e., satiety) duration, on average, 3.5-4 hours after meals. In contrast, in...

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Abstract

The present invention relates to a method and a kit for identifying a subjects macronutrient sensitivity. The method involves assaying a genetic sample from the subject to determine a polymorphism profile, analysing the polymorphism profile to identify risk alleles and determining the macronutrient sensitivity based on the number of risk alleles present. This information can be used for determining an appropriate diet to induce satiety, formulating a diet for inducing satiety, or for treating a range of medical complaints associated with metabolism.

Description

technical field [0001] The present invention relates to a method for identifying the macroelement sensitivity of a receptor. The invention also relates to a method of formulating a satiety-inducing diet and a method for determining satiety in a receptor. Further, the invention relates to a kit suitable for use in the methods of the invention. Background technique [0002] Food consists of three macronutrients and multiple micronutrients. The three macronutrients are carbohydrates, lipids and proteins, while the micronutrients include a variety of compounds including trace minerals and vitamins. [0003] Anthropological research suggests that the evolution of adaptation to specific food types may be behind individual responses to diets differently. In some parts of the world, paleo natural diets are more meat-based and individuals derived from these groups may be better suited to a high-protein, low-carbohydrate diet. Elsewhere in the world, paleo natural diets are more p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/156A61P3/06A61P3/08
Inventor 格雷姆·约翰·史密斯尼克·阿吉罗海伦·阿吉罗哈里·巴纳哈里斯
Owner GENETICS INVESTMENTS
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