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Pharmaceutical composition for prevention and treatment of chronic glomerular diseases and preparation method of pharmaceutical composition

A composition and technology of glomerulonephritis, applied in the direction of drug combination, urinary system diseases, medical preparations containing active ingredients, etc., to achieve the effect of alleviating renal fibrosis

Active Publication Date: 2014-12-17
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patents only disclose the curative effect of treating mesangial proliferative chronic nephritis

Method used

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  • Pharmaceutical composition for prevention and treatment of chronic glomerular diseases and preparation method of pharmaceutical composition
  • Pharmaceutical composition for prevention and treatment of chronic glomerular diseases and preparation method of pharmaceutical composition
  • Pharmaceutical composition for prevention and treatment of chronic glomerular diseases and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] formula:

[0058] 27 parts of Astragalus, 9 parts of Panax notoginseng and 18 parts of Danshen;

[0059] Preparation:

[0060] (1) Prescription quantity Astragalus medicinal material was added with 8 times the weight volume concentration of 60% ethanol for reflux extraction for 3 hours and extracted 3 times to obtain Astragalus extract. The Radix Notoginseng medicinal material was refluxed and extracted by adding 8 times of ethanol with a weight volume concentration of 80% for 3 hours, and extracted 3 times to obtain the Radix Notoginseng extract. Salvia miltiorrhiza medicinal material was added with 6 times the weight volume concentration of 50% ethanol for reflux extraction for 3 hours and extracted 3 times to obtain the salvia miltiorrhiza extract. The extracts were decompressed to recover ethanol, and concentrated to 1.8±0.5g·mL based on the amount of medicinal materials -1 concentration.

[0061] (2) The extracts are respectively absorbed by the macroporous res...

Embodiment 2

[0078] formula:

[0079] 18 parts of Astragalus, 6 parts of Panax notoginseng and 6 parts of Danshen;

[0080] Preparation:

[0081] Mix the medicinal materials of Astragalus membranaceus, Panax notoginseng and Salvia miltiorrhiza in the prescribed amount, then add 10 times of ethanol with a weight volume concentration of 80% to reflux for extraction for 4 hours, extract twice, recover ethanol from the extract under reduced pressure, and concentrate to 1.8±0.3g based on the amount of medicinal materials ·mL -1 Concentration, to obtain the extract;

[0082] (2) Adsorb the extract with a macroporous resin, first elute impurities with water 5 times the weight of the macroporous resin, and then elute impurities with 10% ethanol at a volume concentration 4 times the weight of the macroporous resin;

[0083] (3) Elute with 75% ethanol at a volume concentration 10 times the weight of the macroporous resin, recover ethanol from the eluate under reduced pressure, concentrate, and dr...

Embodiment 3

[0093] formula:

[0094] 10 parts of Astragalus, 3 parts of Panax notoginseng and 4 parts of Danshen;

[0095] Preparation:

[0096] Mix the prescribed amount of astragalus, notoginseng and salvia miltiorrhiza, then add 10 times the weight volume of water to extract at 100°C for 3 hours, extract 4 times, combine the extracts, and concentrate under reduced pressure to 1.5±0.5g·mL based on the amount of medicinal materials -1 Concentration, add ethanol to 70-80%, let stand to precipitate, filter (or centrifuge), filtrate decompresses to recover ethanol, concentrate to 1.8±0.3g·mL based on the amount of medicinal materials -1 Concentration, to obtain the extract.

[0097] (2) Adsorb the extract with a macroporous resin, first elute impurities with water 10 times the weight of the macroporous resin, and then elute impurities with 10% ethanol at a volume concentration 5 times the weight of the macroporous resin;

[0098] (3) eluting with ethanol with a volume concentration of 8 ...

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Abstract

The invention discloses a pharmaceutical composition for prevention and treatment of mesenterium proliferation acute nephritis and focal glomeruloscerosis and a preparation method of the pharmaceutical composition. The pharmaceutical composition is formed by compatibility of extractives of astragalus, panax notoginseng and salviae miltiorrhizae, and effective constituents are flavonoid, saponins and phenolic acid. Medicine materials comprise, by weight, 9-30 parts of the astragalus, 3-10 parts of the panax notoginseng, and 3-20 parts of the salviae miltiorrhizae. Salviae miltiorrhizae contents of all kinds of chemical components include that when calycosin serves as a reference substance, the total flavonoid content is 30.0-0.50%; when total saponins of the panax notoginseseng serves as a reference substance, the total saponins content is 18.0-97.0%; and when caffeic acid serves as a reference substance, the total phenolic acid content is 52.0-2.5%. The inventor of the pharmaceutical composition and the preparation method combines disease-based medicine with vidence-based medicine in long-term clinic treatment. Efficacy of the pharmaceutical composition is superior to single use of any one medicinal component or combined use of two medicinal components. The pharmaceutical composition is little in toxicity and suitable for long-term taking.

Description

technical field [0001] The invention relates to a traditional Chinese medicine effective component composition for preventing and treating mesangial proliferative glomerulonephritis and focal glomerulosclerosis. Specifically, it is a medicinal composition in which effective components of traditional Chinese medicines astragalus, notoginseng and salvia miltiorrhiza are compatible. Background technique [0002] Chronic glomerulonephritis (chronic glomerulonephritis) is abbreviated as chronic nephritis. It is a group of immune diseases that originate in the glomerulus caused by various reasons, with similar clinical manifestations, different pathological changes, and different prognosis. There are different degrees of proteinuria, hematuria, edema and high blood pressure, and most of them end up with different degrees of renal function damage. The clinical onset of chronic kidney disease is insidious, the course of the disease is long, and it has a tendency of progressive deve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K31/7048A61K31/704A61K31/343A61K31/352A61P13/12
Inventor 卢传坚杨霓芝丘小惠刘旭生郑广娟张靖冯兵徐文徐鹏朱莹
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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