Application of valproic acid in preparation of multidrug resistance reversal agent of lung cancer resistance medicine

Abstract

The invention discloses application of valproic acid in preparation of a multidrug resistance reversal agent of a lung cancer resistance medicine, and further discloses application of the valproic acid in the preparation of chemotherapeutics sensitizer of lung cancer resistance and a multidrug resistance tumor invasion resisting and transferring medicine. The application of the valproic acid in the preparation of the multidrug resistance reserval agent of the lung cancer resistance medicine verifies that valproic acid has significant function of a cisplatin persister of human lung cancer resistance through experiments, and verifies that the valproic acid can significantly change drug tolerance of a human lung cancer cell to the cisplatin, improve sensitivity of the human lung cancer cell to the cisplatin, and have obvious restraining effect of invasion effect of the persister of the lung cancer cisplatin.

Description

technical field [0001] The invention relates to the application of valproic acid in the preparation of anti-lung cancer drug multidrug resistance reversal agent. Background technique [0002] According to the "Third National Cause of Death Investigation" report released by the Ministry of Health in April 2008, lung cancer has replaced liver cancer as the number one cause of death from malignant tumors in my country (accounting for 22.7% of all malignant tumor deaths). Lung cancer often has no obvious symptoms in the early stage, especially non-small cell lung cancer (NSCLC), which accounts for 80% of lung cancers. 65-80% of patients are diagnosed in the middle and late stage when they are diagnosed, with distant metastasis, and often lose the opportunity of surgery and radiotherapy; therefore In the treatment of lung cancer, the role of drugs is particularly important. Unfortunately, there is still a lack of long-lasting and effective drugs for the drug treatment of lung ca...

AI Technical Summary

Problems solved by technology

We and Anthony found that after lung cancer cells and colorectal cancer cells become resistant to platinum drugs, the cells will undergo epithelial-mesenchymal transformation (EMT), and their ability to migrate and erode is significantly enhanced compared with their parental lines. This phenomenon makes tumors resistant The hazards of medicinal properties have greatly increased

There is no report that valproic acid can effectively reverse the multidrug resistance of lung cancer cells, thereby improving drug sensitivity

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