Medicine composition with skin whitening effect as well as preparation method and application thereof
A technology for skin whitening and composition, applied in the field of pharmaceutical composition and preparation thereof, can solve the problems of contact dermatitis, increasing the occurrence rate of chromosome exchange and chromosome aberration in ovarian cells, excessive dosage and the like
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Embodiment 1
[0086] At room temperature, take 10 kilograms each of Pyracantha fruit, licorice, mulberry, angelica and saxifrage (50 kilograms in total), soak and extract with 600 kilograms of ethanol with a volume concentration of 70%, and soak for 24 hours. 600 kg of 70% ethanol was soaked for 24 hours to extract, then the soaked solutions were combined, filtered through a 200-mesh filter, concentrated 20 times under reduced pressure, and then the concentrated solution was placed on a macroporous resin and washed with ethanol with a volume concentration of 50%. The collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.
Embodiment 2
[0088] At room temperature, take 8 kg of Pyracantha fruit, 8 kg of licorice, 12 kg of mulberry, 12 kg of angelica and 12 kg of saxifrage (52 kg in total), soak and extract with 1200 kg of ethanol with a volume concentration of 50%, and the soaking time is 24 hour, the residue was soaked in 1200 kilograms of ethanol with a volume concentration of 50% for 24 hours to extract, then the solution after soaking was combined, filtered through a 200-mesh filter screen, concentrated under reduced pressure for 40 times, and then the concentrated solution was covered with macroporous resin. The ethanol with a volume concentration of 40% is used for eluting, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.
Embodiment 3
[0090] At room temperature, take 8 kg of Pyracantha fruit, 8 kg of licorice, 15 kg of mulberry, 15 kg of angelica and 15 kg of saxifrage (61 kg in total), soak and extract with 1000 kg of ethanol with a volume concentration of 80%, and the soaking time is 24 hour, the residue was soaked in 1000 kilograms of ethanol with a volume concentration of 80% for 24 hours to extract, then the soaked solution was combined, filtered through a 200-mesh filter screen and concentrated 25 times, and then the concentrated solution was covered with a macroporous resin, and the concentrated solution was used with a volume concentration of 60 % ethanol for elution, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.
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