Prokinetic traditional Chinese medicinal composition and preparation and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines and provides a prokinetic traditional Chinese medicinal composition. The prokinetic traditional Chinese medicinal composition comprises the following two or three medicinal raw materials in part by weight: 1-120 parts of unprocessed rhizoma atractylodis, 1-30 parts of immature bitter orange and 1-60 parts of unprocessed polygonum multiflorum. The invention further provides a medicinal preparation with the prokinetic traditional Chinese medicinal composition as an active component, and application of the prokinetic traditional Chinese medicinal composition to preparation of medicines and food for treating or preventing irritable bowel syndrome, functional dyspepsia, functional abdominal distension, functional constipation and other gastrointestinal functional lesions.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for promoting gastrointestinal motility, its preparation and application. Background technique [0002] Gastrointestinal functional lesions are caused by disorders of neuromuscular tissue control in the gastrointestinal tract, and are mainly manifested by gastrointestinal symptoms such as pantothenic acid, abdominal distension, constipation, and diarrhea, and there are no structural or biochemical changes in routine examinations. Such as irritable bowel syndrome, functional dyspepsia, etc., are common clinical diseases. Decreased gastrointestinal motility is one of the main manifestations of gastrointestinal functional lesions, and clinical symptoms such as abdominal distension and constipation may appear. [0003] At present, there are four generations of gastrointestinal motility drugs commonly used clinically. T...

AI Technical Summary

Problems solved by technology

The second-generation prokinetic drug is domperidone, which is a peripheral dopamine receptor blocker. It is widely used clinically, mainly to promote gastric motility, but the effect of promoting intestinal motility is not good.

The third generation is cisapride, which is a kind of mehydroclopramide that replaces the alkylated benzodiazepines in its chemical structure. However, in recent years, it has been clinically found that Q-T interval prolongation or torsades de pointes can occur in patients with high sensitivity to cisapride. Tachycardia, for its further clinical application, there is still a lot of controversy

Relatively safe, common adverse reactions include gastric or esophageal and abdominal cramps, bowel whining, diarrhea, abdominal pain, occasional dizziness, nausea, headache, ALT, AST increase, itching, rash and other allergic reactions, and the price is more expensive

[0004] In the technical field of traditional Chinese medicine, single or compound preparations containing laxatives such as rhubarb, senna, and mirabilite are widely used in the above-mentioned clinics, and short-term use often achieves relatively satisfactory results, but long-term use of some drugs is prone to drug resistance ( Such as senna leaf), especially some drugs are likely to induce adverse effects such as intestinal blackening (such as rhubarb) or dehydration of the body after long-term application, thus limiting its clinical application

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