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Artemisia pollen allergen vaccine lozenge and preparation method thereof

An allergen and pollen technology, applied in the directions of allergen antigen components, pill delivery, respiratory system diseases, etc., can solve the problems of inaccurate dosage, large differences, difficult dosage control, etc. Transportation and storage stability

Active Publication Date: 2014-05-07
北京新华联协和药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] However, a shortcoming of sublingual drop vaccine is that the dosage of each drop is difficult to control, the dosage is not accurate, and the difference is large. The preparation of allergen vaccine buccal tablets is more stable than sublingual drops, and can achieve uniformity. drug administration

Method used

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  • Artemisia pollen allergen vaccine lozenge and preparation method thereof
  • Artemisia pollen allergen vaccine lozenge and preparation method thereof
  • Artemisia pollen allergen vaccine lozenge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 Preparation of Artemisia pollen allergen vaccine sublingual tablet (50000AU / tablet)

[0057] Preparation of Artemisia annua pollen allergen, Artemisia grandis pollen allergen, Artemisia mugwort pollen allergen, Artemisia black sand pollen allergen and Artemisia white sand pollen allergen stock solution respectively: by mechanical (vacuum cleaner) collection or hydroponics The pollens of five species of Artemisia were collected and passed through 200-300 mesh sieves to remove dust and other impurities in the pollen, and the purity of the pollen was tested, as well as morphological and molecular biological identification. The degreased pollen is continuously soaked in acetone and stirred to degrease, and the degreased solids are naturally dried. Weigh 100 g each of the defatted Artemisia pollen pollen and add it into 50 mM disodium hydrogen phosphate-sodium dihydrogen phosphate buffer at a feeding ratio of 1:25 (g:mL), and stir at 4 °C for 24 h. The resulting s...

Embodiment 2

[0061] Example 2 Preparation of Artemisia pollen allergen vaccine sublingual tablet (5000AU / tablet)

[0062] According to the method described in Example 1, prepare Artemisia annua pollen allergen, Artemisia grandis pollen allergen, Mugwort pollen allergen, Artemisia black sand pollen allergen and Artemisia white sand pollen allergen stock solution, according to the activity ratio After mixing 1:1:1:1:1, add 4% mannitol to freeze-dry, and the freeze-dried powder (that is, Artemisia pollen allergen vaccine freeze-dried powder) contains 100,000 AU of Artemisia pollen allergen per gram.

[0063] Mix the raw and auxiliary materials according to the following formula:

[0064]

[0065] After the above raw and auxiliary materials are mixed, fully stir, and after mixing evenly, 10,000 pieces of Artemisia pollen allergen sublingual tablet vaccine prepared by direct compression method, each tablet contains 0.1g (containing 5000AU of Artemisia pollen allergen).

Embodiment 3

[0066] Example 3 Preparation of Artemisia pollen allergen vaccine sublingual tablet (500AU / tablet)

[0067] According to the method described in Example 1, prepare Artemisia annua pollen allergen, Artemisia grandis pollen allergen, Mugwort pollen allergen, Artemisia black sand pollen allergen and Artemisia white sand pollen allergen stock solution, according to the activity ratio After mixing 1:1:1:1:1, add 4% mannitol to freeze-dry, and the freeze-dried powder (that is, Artemisia pollen allergen vaccine freeze-dried powder) contains 10,000 AU of Artemisia pollen allergen per gram.

[0068] Mix the raw and auxiliary materials according to the following formula:

[0069]

[0070]

[0071] After the above raw and auxiliary materials are mixed, fully stir, and after mixing evenly, 10,000 pieces of Artemisia pollen allergen sublingual tablet vaccine prepared by direct compression method, each tablet contains 0.1g (containing 500AU of Artemisia pollen allergen).

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Abstract

The invention provides Artemisia pollen allergen vaccine lozenge and a preparation method thereof, wherein the lozenge is prepared by mixing idiotoxins of five kinds of sensitized Artemisia pollens and pharmaceutically acceptable carriers; and the five kinds of sensitized Artemisia plants are Artemisia sieversiana Willd, Artemisia annua L., Artemisia argyi Levl.et Vant, A.ordosica krasch and A.sphaerocep hala krasch. The Artemisia pollen allergen vaccine disclosed by the invention includes idiotoxins of five kinds of main sensitized Artemisia pollens in China; compared with the single Artemisia pollen allergen vaccine, the Artemisia pollen allergen vaccine disclosed by the invention is more effective; furthermore, compared with the sublingual drop, the sublingual lozenge is more steady; and the administration dosage is more accurate.

Description

technical field [0001] The invention relates to the field of allergen vaccine preparation, in particular to an artemisia pollen allergen vaccine buccal tablet and a preparation method thereof. Background technique [0002] Human beings' understanding of allergen diseases began with "hay fever". In 1911, scientists Noon and Freeman used pollen extracts to treat hay fever for the first time, and the treatment of allergen diseases kicked off. The development of the treatment of allergen diseases in China was first introduced from the United States in 1956 by Professor Zhang Qingsong, director of the Department of Otorhinolaryngology of Union Medical College Hospital, and made a breakthrough. It was discovered that the most important autumn-type allergenic pollen in China is Artemisia (Artemisia) plants Pollen provides a basis for the development of domestic allergens and the realization of the localization of allergens. In the 1980s, Ye Shitai and Qiao Bingshan led dozens of h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/36A61K9/20A61P37/08A61P17/00A61P11/02
Inventor 白彩明姜敏裴潇竹汤承祁牛占坡马博晨
Owner 北京新华联协和药业有限责任公司
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