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Preparation method of standard substance for detecting aristolochic acid A in cosmetic

A technology of aristolochic acid and standard substances, which is applied in the field of preparation of standard substances, can solve problems affecting the accuracy of detection and achieve accurate detection results

Inactive Publication Date: 2013-02-27
SHANGHAI INOHERB COSMETIC
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Problems solved by technology

The detection of aristolochic acid A in cosmetics is one of the important safeguards for the safety of cosmetics. At present, direct compound detection methods are mostly used. However, in practical applications, after mixing aristolochic acid A in cosmetics with formula ingredients, There is a big difference between detection and direct compound detection, which will affect the accuracy of detection

Method used

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  • Preparation method of standard substance for detecting aristolochic acid A in cosmetic
  • Preparation method of standard substance for detecting aristolochic acid A in cosmetic
  • Preparation method of standard substance for detecting aristolochic acid A in cosmetic

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Embodiment 1

[0035] According to formula and preparation process in the table, be mixed with cosmetic cream. Aristolochic acid A is prepared into 32mg / 100mL propylene glycol solution, then the propylene glycol solution containing aristolochic acid A is slowly added to the cream, so that the final concentration of aristolochic acid A reaches 30 μg / g, while keeping the temperature constant Stir slowly under the condition of minimum water evaporation, and pack.

[0036] The purity of aristolochic acid A is ≥98.0% (Shanghai Bainian Dande Testing Technology Co., Ltd.).

[0037] Standard substance of the present invention is used to detect the homogeneity test of cosmetic species aristolochic acid A:

[0038] Homogeneity is the most basic attribute of standard materials. The project randomly selects n bottles of standard materials developed in accordance with the "Guidelines for Standard Sample Work (5): General Rules for Chemical Composition Standard Sample Technology" (GB / T15000.9-94), and O...

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Abstract

The invention relates to a preparation method of a standard substance for detecting aristolochic acid A in a cosmetic. The preparation method is characterized in that a propylene glycol solution of the aristolochic acid A is mixed with cosmetic cream to form the standard substance for detecting the aristolochic acid A in the cosmetic. The formula of the cosmetic cream comprises a phase A, a phase B, a phase C and a phase D in percentage by weight, namely the phase A comprises 3 to 5 percent of stearate, 2 to 4 percent of alcohol and 10 to 14 percent of #26 white oil; the phase B comprises 38 to 42 percent of propylene glycol, 0.1 to 0.3 percent of carbomer and 36 to 42 percent of deionized water; the phase C comprises 0.1 to 0.3 percent of triethanolamine, and the phase D comprises 1.25 to 1.30 percent of phenoxyethanol and ethylhexylglycerin; and the concentration of the arecoline in the standard substance is 50 mug / g. The preparation method has the advantages that the aristolochic acid A is mixed with the cosmetic cream to form the standard substance for detecting the aristolochic acid A in the cosmetic; the standard substance is the same as that in a cosmetic sample containing the aristolochic acid A in actual use, so that detection on the aristolochic acid A in the cosmetic can accord with an application state; and the detection is relatively accurate.

Description

technical field [0001] The invention relates to a method for preparing a standard substance for detecting aristolochic acid A in cosmetics. The method is to mix aristolochic acid A with a cosmetic cream through a certain technical method to form a standard substance for detecting aristolochic acid A in cosmetics. Standard substance of dochlic acid A. Background technique [0002] Aristolochic acid A is a kind of nitro-containing phenanthrene organic acid, which mainly exists in Aristolochia Aristolochia plants, and has obvious nephrotoxicity. The detection of aristolochic acid A in cosmetics is one of the important safeguards for the safety of cosmetics. At present, direct compound detection methods are mostly used. However, in practical applications, after mixing aristolochic acid A in cosmetics with formula ingredients, There is a big difference between detection and direct compound detection, which will affect the accuracy of detection. Compared with standard compounds,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/00G01N30/06
Inventor 赵鑫王改香朱锡菊唐晓军张宝月张磊黄蓉赵春霞
Owner SHANGHAI INOHERB COSMETIC
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