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Rapid-curing adhesive bone repair material and preparation method thereof

A technology for bone repair and curing solution, applied in the field of medical materials, can solve the problems of prolonging curing time, unable to fully meet clinical needs, etc. Effect

Active Publication Date: 2012-10-03
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology makes use of an organic compound called citric acid (C6H8O2) for improved properties like faster setting times, stronger binding ability when used together, better stability during storage over longer periods without losing their original shape after being applied on hard tissues. Additionally, this new type of composition includes naturally occurring polymers made from sugars attached by carboxyl groups through ester linkages between them which create strong cohesiveness even if they are mixed into another substance beforehand. These technical features help prevent collapsed implants caused due to poor hydration conditions.

Problems solved by technology

This patented technical problem addressed in this patents relates to developing a new composition called collagen spondyberkine cements that could effectively fill cracks without causing harmful side effects like inflammations due to their rapid solidifying nature. Current methods require prolonged dry times while still being effective, leading to complications from delayed union between different parts of the body's skeleton.

Method used

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  • Rapid-curing adhesive bone repair material and preparation method thereof
  • Rapid-curing adhesive bone repair material and preparation method thereof
  • Rapid-curing adhesive bone repair material and preparation method thereof

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preparation example Construction

[0108] The preparation method of the bone repair material provided by the invention comprises the steps of:

[0109] The bone repair material is obtained by mixing the solid powder and the solidifying liquid at a solid-liquid ratio of 0.8:1 to 4:1 g / mL.

[0110] In another preferred example, the solid-liquid ratio is 1.2:1-3:1 g / mL, preferably, the solid-liquid ratio is 1.6:1-2.5:1 g / mL.

[0111] In another preferred example, the solid-to-liquid ratio is 2:1 g / mL.

[0112] Wherein, the preparation method of curing liquid is as follows:

[0113] (i) prepare organic acid aqueous solution, mass percent concentration is 5%~40%;

[0114] (ii) Dissolving natural polysaccharides, natural polysaccharide derivatives or combinations thereof in an aqueous organic acid solution to form a solidified solution, wherein the mass percent concentration of the natural polysaccharides, natural polysaccharide derivatives or combinations thereof is 1wt% to 5wt%.

[0115] In another preferred exa...

Embodiment 1

[0142] Prepare a 5wt% citric acid aqueous solution, add chitosan and sodium alginate to obtain a solidified solution, which contains 1wt% chitosan and 1wt% sodium alginate. Weigh 0.4g of calcium phosphate bone cement powder, add 0.5mL of curing solution, and mix the bone cement powder and curing solution evenly.

[0143] Put the paste into the simulated body fluid, then place it in the shaking box (100r / min) and vibrate for 24 hours, observe the water resistance performance, see the results figure 2 ,Depend on figure 2 It can be seen that after adding citric acid to the curing solution, the water resistance of the bone bonding material is better improved.

[0144] After testing, the setting time is 19min, the compressive strength is 15MPa, and the bonding strength is 26N·cm -2 .

Embodiment 2

[0146] Prepare 40wt% citric acid aqueous solution, add chitosan and sodium alginate to obtain a solidified solution, which contains 1wt% chitosan and 5wt% sodium alginate. Weigh 0.4g of calcium phosphate bone cement powder, add 0.2mL of curing solution, and mix the bone cement powder and curing solution evenly. The setting time is 8min, and the compressive strength is 52MPa after complete drying, and the bonding strength is 43N·cm -2 .

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Abstract

The invention discloses a rapid-curing adhesive bone repair material and a preparation method of the repair material. The material is prepared by blending solid powder and curing solution, wherein the solid powder is phosphate bone cement powder, and the curing solution is prepared by dissolving natural polysaccharides or derivatives of the natural polysaccharides or combination of the natural polysaccharides or the derivatives in organic acid solution. The solid powder can be rapidly cured when being mixed with the curing solution, to obtain repair material with excellent collapse resistance, high mechanical strength and good biocompatibility and degradability. The material can be used for preparing bonding resetting material of bone fragments in case of comminuted fracture and intra-articular fracture, preparing bonding fixing material of artificial joint and internal fixation device, and also preparing filling material of fracture gap and bone defect.

Description

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Claims

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Application Information

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Owner EAST CHINA UNIV OF SCI & TECH
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