Application of 5-(4-hydroxyl-3-methoxybenzylidene)rhodanine to preparation of medicament for treating Parkinson's disease

Abstract

The invention relates to an application of 5-(4-hydroxyl-3-methoxybenzylidene)rhodanine to preparation of a medicament for treating a Parkinson's disease.

Description

technical field [0001] The present invention relates to the use of 5-(4-hydroxy-3-methoxybenzylidene) rhodamine in preparing medicine for treating Parkinson's disease. Background technique [0002] 5-(4-Hydroxy-3-methoxybenzylidene) rhodanine (5-(4-Hydroxy-3-methoxybenzylidene) rhodanine) is a well-known compound, molecular weight: 267.32. According to U.S. Patent No. 5,523,314 and European Patent Application No. 93306959.3, such compounds and their derivatives have been used to treat diabetes or Alzheimer's disease. [0003] 5-(4-Hydroxy-3-methoxybenzylidene) rhodamine has the following chemical structure: [0004] [0005] Parkinson's disease (PD) is also known as "paralysis tremor", Parkinson's disease or Parkinson's disease. It is a chronic progressive movement disorder common in the elderly. The earliest systematic description of the disease was by British physician James Parkinson. Tremor palsy". Clinical manifestations are resting tremor, muscle rigidity, brady...

AI Technical Summary

Problems solved by technology

[0013] 2. Although the treatment is often interrupted, most of the patients cannot control the disease well, and the disease will be repeated and exacerbated to varying degrees

[0014] 3. For patients who start treatment at an advanced stage, the condition is often very serious, and the existing treatment methods are also limited in improving the condition, and the patient usually has obvious disabilities

[0020] There is no report in the prior art that 5-(4-hydroxy-3-methoxybenzylidene) rhodanine has curative effect on Parkinson's disease

Images