Production method of p-trifluoromethyl chlorobenzene

A technology of p-chlorobenzotrifluoride and production method, which is applied in the direction of halogen substitution preparation, organic chemistry, etc., and can solve the problems of low content of finished products, low product yield, complicated production methods, etc.

Inactive Publication Date: 2012-07-25
江苏优普生物化学科技股份有限公司
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AI Technical Summary

Problems solved by technology

[0002] The existing production method of p-chlorobenzotrifluoride is complicated, the product yield is low, and the finished product content is low

Method used

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Embodiment Construction

[0013] A kind of production method of p-chlorobenzotrifluoride, comprises the following steps:

[0014] (1) Chlorination: Add p-chlorotoluene to the chlorination kettle, pass in chlorine gas and carry out chlorination at 90-100°C for 16-20 hours. After the chlorination is completed, aerate to remove hydrogen chloride to obtain p-chlorotrichloromethylbenzene ;

[0015] (2) Fluorination: Put the obtained p-chlorotrichloromethylbenzene into a high-pressure fluorination kettle, feed HF, and perform fluorination reaction at 1.5MPa and 100°C for 6-8 hours to obtain p-chlorobenzotrifluoride, and then reduce Press and release the material, and carry out rectification after drying to obtain a finished product with a p-chlorobenzotrifluorotoluene content of more than 99.5%.

[0016] The molar ratio of p-chlorotoluene to chlorine in step (1) is 1:3~3.5 (eg 1:3, 1::3.2, 1:3.5).

[0017] The molar ratio of p-chlorotrichloromethylbenzene to HF in step (2) is 1:3.2.

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Abstract

The invention discloses a production method of p-trifluoromethyl chlorobenzene, which comprises the following steps: adding p-chlorotoluene in a chlorinating reactor, introducing chlorine gas to perform chlorination at 90-100 DEG C for 16-20 hours, and performing aeration to remove hydrogen chloride after the chlorination is finished, and obtaining p-chlorotrichlorotoluene; and adding obtained p-chlorotrichlorotoluene into a high pressure fluorinating reactor, introducing HF, performing fluoridation at 100 DEG C and under a pressure of 1.5MPa for 6-8 hours, and obtaining p-trifluoromethyl chlorobenzene. The production method of trifluoromethyl chlorobenzene disclosed by the invention is simple and convenient, and easy to operate, and the product content after rectification is up to over 99.5%.

Description

technical field [0001] The invention relates to a production method of p-chlorobenzotrifluoride. Background technique [0002] The existing production method of p-chlorobenzotrifluoride is complicated, the product yield is low, and the finished product content is low. Contents of the invention [0003] The object of the present invention is to provide a kind of easy operation, the production method of high p-chlorobenzotrifluoride of finished product content. [0004] Technical solution of the present invention is: [0005] A kind of production method of p-chlorobenzotrifluoride is characterized in that: comprise the following steps: [0006] (1) Chlorination: Add p-chlorotoluene to the chlorination kettle, pass in chlorine gas and carry out chlorination at 90-100°C for 16-20 hours. After the chlorination is completed, aerate to remove hydrogen chloride to obtain p-chlorotrichloromethylbenzene ; [0007] (2) Fluorination: Put the obtained p-chlorotrichloromethylbenzene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C25/13C07C17/20
Inventor 陶坤山张建华张继钱徐国军
Owner 江苏优普生物化学科技股份有限公司
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