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Preparation method for compound salvia miltiorrhiza preparation and antioxidant activity thereof

A technology for compound salvia and anti-oxidation, applied in the research and development field of pharmaceutical products, can solve the problems of antioxidant toxicity, carcinogenicity, etc.

Inactive Publication Date: 2013-10-23
SHANDONG UNIV AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, synthetic antioxidants have certain toxicity and carcinogenic effects.

Method used

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  • Preparation method for compound salvia miltiorrhiza preparation and antioxidant activity thereof
  • Preparation method for compound salvia miltiorrhiza preparation and antioxidant activity thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. a preparation method of compound salvia miltiorrhiza preparation with antioxidant effect, is characterized in that comprising following process:

[0018] (1) The weight ratio of raw materials is: Salvia miltiorrhiza 9g, Epimedium 6g, Porphyridium 10g;

[0019] (2) Add 8 times the amount of Salvia Miltiorrhiza and Epimedium to 70% ethanol to extract 8 times at room temperature, then seal and sonicate for 30 minutes at a temperature of 30°C and a power of 80W, then filter with gauze, and use 6 times the amount and 4 times of the filter residue respectively Multiple times of 70% ethanol was repeatedly extracted once, filtered to obtain the filtrate;

[0020] (3) The filtrate in (2) is combined, ethanol is reclaimed, obtains Salvia miltiorrhiza, Epimedium extract;

[0021] (4) Centrifuge Porphyridium algae with a 5000r / min centrifuge for 10min, then suspend it in pH 7.4, 50mmol / L phosphate buffer, perform ultrasonic crushing, break for 5s, interval 5s, 20 times, use 100...

Embodiment 2

[0025] 1. a preparation method of compound salvia miltiorrhiza preparation with antioxidant effect, is characterized in that comprising following process:

[0026] (1) The weight ratio of raw materials is: Salvia miltiorrhiza 12g, Epimedium 9g, Porphyridium 20g;

[0027] (2) Add 10 times the amount of Salvia Miltiorrhiza and Epimedium to 70% ethanol to extract at room temperature for 10 hours, then seal and sonicate for 30 minutes at a temperature of 30°C and a power of 80W, then filter with gauze, and filter the residue with 6 times the amount and 4 Multiple times of 70% ethanol was repeatedly extracted once, filtered to obtain the filtrate;

[0028] (3) The filtrate in (2) is combined, ethanol is reclaimed, obtains Salvia miltiorrhiza, Epimedium extract;

[0029] (4) Centrifuge Porphyridium algae with a 5000r / min centrifuge for 10min, then suspend it in pH 7.4, 50mmol / L phosphate buffer, perform ultrasonic crushing, break for 5s, interval 5s, 20 times, use 10000r / min high s...

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Abstract

The invention belongs to the technical field of research and development of medical products, and relates to a preparation method for a compound salvia miltiorrhiza preparation and antioxidant activity thereof. The method comprises the following steps of: adding salvia miltiorrhiza and epimedium herb into 70 percent ethanol to lixiviate at room temperature; performing ultrasonic processing for 30 minutes at the temperature of 30 DEG C and at the power of 80 W; filtering; repeatedly extracting filter residue by using 70 percent ethanol in an amount which is 6 times the amount of the filter residue and in an amount which is 4 times the amount of the filter residue respectively; filtering; combining filtrates; recovering the ethanol to obtain salvia miltiorrhiza and epimedium herb extract; centrifuging porphyridium cruentum by using a centrifuge of 5,000r / min for 10 minutes; suspending in 50mmol / L phosphoric acid buffer solution with pH of 7.4; performing ultrasonic crushing; centrifuging by using a high-speed freezing centrifuge to obtain supernatant; freeze-drying to obtain a dry product; and uniformly mixing the dry product with the salvia miltiorrhiza and epimedium herb extract to obtain the compound salvia miltiorrhiza preparation. The product has an antioxidant effect.

Description

technical field [0001] The invention belongs to the technical field of research and development of pharmaceutical products. The invention relates to a preparation method of a compound salvia miltiorrhiza preparation and its antioxidant activity. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge. Bitter, slightly cold. GUIXIN, Liver Channel. Promoting blood circulation and regulating menstruation, dispelling blood stasis and relieving pain, cooling blood and eliminating carbuncle, clearing away heart-fire and restlessness, nourishing blood and calming the nerves. Indications for irregular menstruation, amenorrhea and dysmenorrhea, accumulation of lumps in the abdomen, tingling pain in the chest and abdomen, heat pain, sore swelling and pain, restlessness and insomnia; hepatosplenomegaly, angina pectoris. The root mainly contains fat-soluble diterpenoids and water-soluble phenolic acids, as well as flavonoids, triterpe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P39/06
Inventor 张崇禧侯欣池张成城郑友兰
Owner SHANDONG UNIV AT WEIHAI
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