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Traditional Chinese medicine composition for treating cerebral apoplexy and its preparation method

A composition and brain stroke technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of rarely using fresh medicinal materials, unfavorable therapeutic effect, and medicinal material damage, so as to maintain spatial structure and Physiological activity, improvement of clinical curative effect, effect of ensuring curative effect

Active Publication Date: 2013-06-26
北京鲜动物药研制中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the vast majority of Chinese patent medicines on the market for the treatment of cerebral apoplexy use herbal medicines as raw materials, especially dry medicinal materials, and rarely use fresh medicinal materials, which seriously limits and affects the efficacy of Chinese patent medicines.
In the preparation process of its medicine, strong acid, strong alkali and organic solvent are also added, or it is carried out under high temperature, high pressure and other conditions, which have formed certain damage and interference to the medicinal material itself and its active ingredients. It is not conducive to its proper therapeutic effect

Method used

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  • Traditional Chinese medicine composition for treating cerebral apoplexy and its preparation method
  • Traditional Chinese medicine composition for treating cerebral apoplexy and its preparation method
  • Traditional Chinese medicine composition for treating cerebral apoplexy and its preparation method

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Effect test

Embodiment 1

[0039] Embodiment 1: Chinese medicine composition prescription and preparation method of the present invention

[0040]

[0041]

[0042] Preparation method: Homogenize fresh groundworm, fresh leech, and fresh ground beetle with purified water for 30 minutes, freeze the homogenate at -30°C for 24 hours, take it out, melt it at room temperature (20-30°C), and filter , the filtrate is first centrifuged at low speed (1000 rpm, centrifugation time 0.25min / L), and the centrifugate is collected and then subjected to high-speed centrifugation (13000 rpm, centrifugation time 0.5min / L) to obtain high-speed centrifugation liquid, ultrafiltration cut-off molecular weight 20000Da The following components, the ultrafiltrate is concentrated by reverse osmosis to remove water, and then vacuum freeze-dried to obtain a freeze-dried powder, and then 70 g of ginseng and 70 g of Panax notoginseng are crushed into fine powder, and combined with the above freeze-dried powder to obtain.

Embodiment 2

[0043] Embodiment 2: Chinese medicine composition prescription and preparation method of the present invention

[0044]

[0045] Preparation method: Homogenize fresh earthworm, fresh leech, and fresh ground beetle with purified water for 30 minutes, freeze the homogenate at -20°C for 24 hours, take it out, melt it at room temperature (20-30°C), and filter , the filtrate is first centrifuged at a low speed (1400 rpm, centrifugation time 0.25min / L), and the centrifugate is collected and then subjected to high-speed centrifugation (15000 rpm, centrifugation time 0.5min / L) to obtain a high-speed centrifuge, and the ultrafiltration cut-off molecular weight is 20000Da For the following components, the ultrafiltrate is concentrated by reverse osmosis to remove water, and then freeze-dried in a vacuum to obtain a freeze-dried powder. Then, 100 g of ginseng and 100 g of Panax notoginseng are crushed into fine powders, and combined with the above-mentioned freeze-dried powder to obtai...

Embodiment 3

[0046] Embodiment 3: Chinese medicine composition prescription and preparation method of the present invention

[0047]

[0048]

[0049] Preparation method: Homogenize fresh groundworm, fresh leech, and fresh ground beetle with purified water for 30 minutes, freeze the homogenate at -25°C for 24 hours, take it out, melt it at room temperature (20-30°C), and filter , the filtrate is first centrifuged at low speed (1200 rpm, centrifugation time 0.25min / L), and the centrifugate is collected and then subjected to high-speed centrifugation (14000 rpm, centrifugation time 0.5min / L) to obtain high-speed centrifugation liquid, ultrafiltration molecular weight cut-off 20000Da The following components, the ultrafiltrate is concentrated by reverse osmosis to remove water, and then vacuum freeze-dried to obtain a freeze-dried powder, and then 83 g of ginseng and 83 g of Panax notoginseng are crushed into fine powder, and combined with the above freeze-dried powder to obtain the prod...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating cerebral apoplexy, which comprises the active components containing the following raw materials by ratio: 70-100 parts of gen-seng, 450-550 parts of fresh lumbricus, 200-300 parts of fresh leech, 200-300 parts of fresh ground beetle and 70-100 parts of pseudo-ginseng. The present invention also discloses a preparationmethod of the traditional Chinese medicine composition. The method avoids high temperature, high pressure, strong acid, strong base and an organic solvent treatment in the traditional technology during the preparation process, maximally keeps the space structure and the physiological activity of the active substances as well as ensures the curative effects of the traditional Chinese medicine composition.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating cerebral apoplexy and a preparation method thereof. Background technique [0002] In the past 30 years, the incidence and prevalence of stroke in my country have been on the rise. Its incidence rate is about 1.5-2 million per year, 2 million stroke events occur every year, and the death toll exceeds 1.2 million. [0003] Cerebral stroke is also known as cerebral apoplexy. Chinese medicine believes that stroke is due to imbalance of yin and yang, qi and blood disorder, resulting in sudden fainting, unconsciousness, hemiplegia, and oblique mouth and eyes; Slanting, poor speech, and partial body numbness are the main manifestations of a disease. Stroke is divided into two categories: hemorrhagic stroke and ischemic stroke. The vast majority of stroke is ischemic stroke, and its incidence acco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P9/10A61K35/62A61K35/64
Inventor 李建生
Owner 北京鲜动物药研制中心
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