Serum pharmacochemistry preparation method of Chinese medicinal weight-reducing prescription

A technology of traditional Chinese medicine and prescription, which is applied in the field of serum drug chemistry preparation of traditional Chinese medicine weight loss prescription, which can solve the problems of small content of active ingredients and difficult detection

Inactive Publication Date: 2012-02-08
杨槐
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Problems solved by technology

The second problem that may be encountered is that the content of active ingredients in the drug-containing serum is very small, and detection is difficult. In this case, modern instrumental analysis methods should be introduced as much as possible

Method used

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Experimental program
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Embodiment Construction

[0006] 1. To screen a compound Chinese medicine prescription with clear mechanism of action and good weight loss effect, laying the foundation for the development of compound weight loss Chinese medicine.

[0007] 2. Discover new compounds related to weight loss from drug-containing serum, track and isolate them until their structure identification, and provide leading compounds for innovative drug research.

[0008] 3 On the basis of literature research, collect weight-loss compound preparations, extract with alcohol or water according to conventional methods of traditional Chinese medicine, and prepare extracts, and use the same extract to prepare drug-containing serum in rats, using NPY Y5R, NMU2R, MC4R and other gene clones constructed stably expressed cell lines and G-protein coupled receptor reporter gene analysis method, screened, and determined the compound to be studied in the work.

[0009] 4. Disassemble the compound prescription obtained from the screening to prepa...

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Abstract

The invention relates to a serum pharmacochemistry preparation method of a Chinese medicinal weight-reducing prescription. Obesity can cause a series of diseases, such as hypertension, diabetes mellitus, heart diseases, cerebrovascular diseases, cancers, cholecystitis, infections and the like. At present, clinical medicaments for treating the obesity are all brain appetite inhibitor and have higher side effects after long-term use, thus, the clinical medicaments are only used in a short term in a limitation manner in most countries. The traditional Chinese medicine has originality for treating the obesity in China, and most weight-reducing prescriptions are low in toxic or side effects and are safe and effective in long-term use. According to the invention, a traditional Chinese medicine serum pharmacochemistry method is intended to be used, two or three effective Chinese medicinal weight-reducing prescriptions are finely selected by using a chemical fingerprint technology and a targeted gene high-throughput sieving technology, multi-target-point weight-reducing genes are used to determine bioactivity, and active compounds are traced and separated, so that the foundation for developing a new weight-reducing medicine is laid.

Description

【Technical field】 [0001] The invention relates to a chemical preparation method of serum medicine for weight loss prescription of traditional Chinese medicine. In particular, a compound prescription with definite curative effect is selected from traditional Chinese medicine weight loss prescription. for the discovery of new active monomers. 【Background technique】 [0002] As a result of the obesity gene-targeted drug screening, there is no response to the receptor genes used, but this does not mean that these traditional Chinese medicines have no effect, because the receptor genes we use are limited. In this case, it is possible to study from multiple angles by changing the system used to measure the activity. Or use proteomics techniques for research. The second problem that may be encountered is that the content of active ingredients in the drug-containing serum is very small and difficult to detect. In this case, modern instrumental analysis methods should be introduced...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00G01N33/96G01N30/86A61P3/04
Inventor 杨槐
Owner 杨槐
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