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Biodegradable filling for restoration of alveolar bone

A bone repair and decomposing technology, applied in medical science, dentistry, dental preparations, etc., can solve problems such as skewed teeth, insufficient alveolar bone height or width, and inability to grow enough

Active Publication Date: 2011-11-23
SUNMAX BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in such a short period of time, the bone cells in the patient's alveolar cannot grow enough bone tissue, so that the new alveolar bone cannot return to its original integrity, and because the new alveolar bone tissue does not need support around it. Tooth, so these tissues will be absorbed by the patient's body over time, which is the so-called alveolar bone atrophy, which will exacerbate the lack of height or width of the alveolar bone, which may cause the normal teeth around the missing tooth to be skewed

Method used

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  • Biodegradable filling for restoration of alveolar bone
  • Biodegradable filling for restoration of alveolar bone
  • Biodegradable filling for restoration of alveolar bone

Examples

Experimental program
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Effect test

preparation example Construction

[0046] Preparation of cross-linked collagen fibers

[0047] Add atelocollagen with a concentration of 3.0±0.5mg / mL to 0.2M phosphate buffer solution, adjust the pH value to 7.0±0.2, keep stirring for 4 hours, then add glutaraldehyde with a final concentration of 0.003%. Or use 1-ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) with a final concentration of 0.004% and N-hydroxysuccinimide (NHS) with a final concentration of 0.0016% as a cross-link agent, and adjust the pH value to 5.5±0.2, control the temperature at 35±5°C and keep stirring for 16 hours to carry out the chemical crosslinking reaction.

[0048] After the chemical cross-linking reaction, the cross-linked collagen fibers were miniaturized with a homogenizer, which was homogenized at 10000±200rpm for 10±2 minutes, and then centrifuged at a centrifugal force of 14000G for 1 hour to collect the cross-linked collagen fibers The concentration of the precipitate, resulting cross-linked collagen fibers generally ranges ...

Embodiment 1

[0056] Using biphasic phosphate as support particles, tricalcium phosphate (β-TCP) with a particle size of 0.5 to 2.0 mm and hydroxyl apatite (HAP) with a particle size of 0.075 to 0.150 mm are used to 60%: 40% weight ratio mixed.

[0057] Take the 30±0.2 mg / mL cross-linked collagen fiber slurry prepared above, and mix the above HAP / β-TCP complex into the cross-linked collagen fiber slurry, wherein the cross-linked collagen fiber slurry: HAP The / β-TCP complex was mixed in a weight ratio of 30%:70%.

[0058] The molding method of the biodegradable filling material used for alveolar bone repair in this embodiment can be referred to Figures 1A to 1C . First, if Figure 1A As shown, a forming mold 10 is prepared, which has a forming groove 101. The inner diameter of the forming groove 101 gradually decreases from the opening to the inside like a trumpet, and its bottom is arc-shaped, so that the subsequent fillings are formed as a whole. Domed cone. The diameter of the openi...

Embodiment 4

[0068] HAP / β-TCP complex and bioactive glass were used as support particles, in which tricalcium phosphate (β-TCP) / hydroxyapatite (HAP) with particle size between 0.5 and 1.0 mm and particle size between Bioactive glass at 150 to 600 μm.

[0069]Take the 30±0.2 mg / mL cross-linked collagen fiber slurry prepared above, mix HAP / β-TCP complex and bioactive glass into the cross-linked collagen fiber slurry, wherein the cross-linked collagen fiber Slurry:HAP / β-TCP complex:bioactive glass was mixed in a weight ratio of 30%:35%:35%.

[0070] The molding method of the biodegradable filling material used for alveolar bone repair in this embodiment can be referred to Figures 6A to 6G . First, if Figure 6A As shown, a forming mold 12 is prepared, which has a forming groove 112. The inner diameter of the forming groove 112 is approximately the same from the opening to the inside, but the inner diameter gradually decreases until the bottom, so that the subsequent fillings are formed in...

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Abstract

The invention relates to a biodegradable filling for the restoration of an alveolar bone, comprising first crosslinking type collagen fibers and supporting granules, wherein the first crosslinking type collagen fibers are prepared by reacting a crosslinking agent with non-crosslinked collagen fibers; and the supporting granules are biomedical ceramic granules, bioactive glasses or combinations ofthe biomedical ceramic granules and the bioactive glasses and distributed in the first crosslinking type collagen fibers.

Description

technical field [0001] The invention relates to a biodegradable filling for alveolar bone repair, in particular to a biodegradable and plastic biodegradable filling for alveolar bone repair. Background technique [0002] In the past, when a patient's tooth could not maintain its original function due to external force fracture, tooth decay, periodontal disease or lesions around the root tip, the tooth was extracted and the bleeding was stopped with sterile fiber gauze for the cavity trauma area caused by tooth extraction and repair wounds. However, the disadvantage of using fibrous gauze is that it can only stop bleeding, it is not absorbed by patients, and it is easy to embed food residue, so it is easy to cause wound infection and make the wound take longer to repair. [0003] In recent years, collagen tooth filling products have appeared. This type of collagen tooth filling is only composed of collagen, which can be completely absorbed by organisms and has a three-dimens...

Claims

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Application Information

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IPC IPC(8): A61K6/033A61K6/027A61K6/02A61K6/838
Inventor 林建兴林育德卢香吟王进富谢达仁
Owner SUNMAX BIOTECH
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