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Hepatic progenitor cells and uses thereof

A technology of progenitor cells and cells, applied in the field of preparation of hepatic progenitor cells, can solve problems such as obstruction of liver transplantation, lack of donors, inappropriateness, etc.

Active Publication Date: 2011-11-09
GWOXI STEM CELL APPL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Hepatitis B, hepatitis C, alcohol and certain chemical drugs can lead to liver fibrosis and cirrhosis, and eventually lead to liver failure. At present, liver transplantation is still the only option for patients with liver failure. However, liver transplantation is often hindered by lack of donors At the same time, liver transplantation is not suitable for some diseases, such as certain infections and certain types of cancer, so some alternative methods are needed to treat liver diseases and related problems

Method used

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  • Hepatic progenitor cells and uses thereof
  • Hepatic progenitor cells and uses thereof
  • Hepatic progenitor cells and uses thereof

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Embodiment Construction

[0037] The present invention relates to pluripotent cells and methods of using pluripotent cells to treat liver diseases.

[0038]The use of stem cells to treat liver diseases has been documented in the medical literature due to their reparative properties and potential for differentiation. However, ethical and logistical considerations have hindered the use of embryonic stem cells. Stem cells obtained from bone marrow and umbilical cord It has the potential to become a variety of cells and hepatic progenitor cells. At the same time, in vivo studies have also confirmed that transplanted stem cells can differentiate into hepatic progenitor cells, and express albumin, tryptophan 2, 3 dioxygenase and cytokeratin 18 (CK18 ) specific markers, and studies have also confirmed that transplanted mouse stem cells can accelerate the recovery of the animal after liver injury.

[0039] The present invention uses Wharton's jelly stem cells (Wharton's jelly stem cells) to obtain hepatic prog...

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Abstract

The invention provides a preparation method and uses of hepatic progenitor cells. The preparation method comprises acquiring processed materials having cultured multifunctional zooblasts. The processed materials show a positive reaction to the mark of a group selected from CD29, CD44, CD49b, CD49d, CD73, CD90, CD105, CD 13 and HLA-DR, and shows a negative reaction to the mark of a group selected from CD14, CD34 and CD45. The preparation method also comprises the step of culturing zooblasts and liver tissues in nutrient solution for a certain period of time, and collecting the progeny of the multifunctional zooblasts cultured together to obtain hepatic progenitor cells. The multifunctional zooblasts are Wharton's jelly extracted from an umbilical cord of a first experiment object. The multifunctional hepatic progenitor cells can treat hepatopathy and other relevant problems.

Description

technical field [0001] The invention relates to a technology of hepatic progenitor cells, in particular to a preparation method and application of hepatic progenitor cells. Background technique [0002] Chronic liver disease is a serious health problem worldwide. Hepatitis B, hepatitis C, alcohol and certain chemical drugs can lead to liver fibrosis and cirrhosis, and eventually lead to liver failure. At present, liver transplantation is still the only option for patients with liver failure. However, liver transplantation is often hindered by lack of donors At the same time, liver transplantation is not suitable for certain diseases, such as certain infections and certain types of cancer, so some alternative methods are needed to treat liver disease and its related problems. Contents of the invention [0003] The present invention is based on the unexpected discovery that multifunctional hepatic progenitor cells can be used to treat liver disease and related problems. ...

Claims

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Application Information

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IPC IPC(8): C12N5/071A61K35/407A61P1/16A61K35/545
CPCC12N2506/025A61K35/407A61K35/545C12N5/067C12N2502/14A61K35/12A61P1/16
Inventor 韩鸿志林欣荣
Owner GWOXI STEM CELL APPL TECH CO LTD
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