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Valsartan compound and new manufacturing method thereof

A technology for valsartan and compounds, which is applied in the field of refining valsartan compounds, can solve the problems of undisclosed purification of valsartan, and achieve the effects of reducing toxic and side effects, mild reaction conditions, and high yield

Inactive Publication Date: 2011-06-15
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For these impure products, the prior art does not disclose the method for purifying valsartan. In fact, those skilled in the art with general experience clearly know that they face various difficulties in obtaining high-purity and high-yield compounds. All of these are by no means According to the existing general separation and purification theory, it can be expected to be solved, and many difficulties need to be overcome

Method used

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  • Valsartan compound and new manufacturing method thereof
  • Valsartan compound and new manufacturing method thereof
  • Valsartan compound and new manufacturing method thereof

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Abstract

The invention provides a valsartan compound and a new manufacturing method thereof. In the invention, through specially designed methods for acid and alkali conversion and absorption by macroporous absorption resin, the aim of refining and purifying can be fulfilled; and thus, the high-purity valsartan compound is obtained, the product quality of the preparation is improved, the toxic and side effects are reduced, and the clinic medicine safety of the valsartan in the preparation of antihypertensive medicines is guaranteed.

Description

Valsartan compound and its new preparation method technical field The invention relates to a refining method of a valsartan compound, which can obtain high-purity valsartan, and belongs to the technical field of medicine. Background technique Valsartan, chemical name: N-(1-pentanoyl)-N-[4-[2-(1H-tetrazol-5-yl)phenyl]-L-valine, molecular formula : C24H29N5O3, molecular weight: 435.52, structural formula: Valsartan is an antihypertensive drug, white powder, odorless, tasteless, easily soluble in methanol, soluble in chloroform, almost insoluble in water, developed by Swiss Novartis, and launched in 1996. Angiotensin, the main active substance of the renin-angiotensin system, is a powerful vasoconstrictor polypeptide, and its biological functions are mainly reflected in the regulation of vascular tension, blood flow, promotion of cell growth, proliferation and inflammation . Valsartan is a non-peptide angiotensin (AT) II receptor antagonist, which can antagonize the s...

Claims

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Application Information

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IPC IPC(8): C07D257/04A61P9/12
Inventor 杨明贵
Owner HAINAN MEILAN SMITH KLINE PHARMA
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